1-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

Base Information

Chemical Name:1-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzyl)azetidine-3-carboxylic acid
CAS No.:1344996-01-5
Molecular Formula:C₂₅H₂₆F₃N₃O₃S
Molecular Weight:505.561
Hs Code.:

Synonyms:1-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

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Chemical Property of 1-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

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Technology Process of 1-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

There total 11 articles about 1-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzyl)azetidine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₆H₂₈F₃N₃O₃S

: 1344996-01-5
1-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

Guidance literature:: C₂₆H₂₈F₃N₃O₃S; With water; sodium hydroxide; In isopropyl alcohol; at 90 ℃; for 2h;

In water; pH=3 - 4;

Reference yield:

: 1260023-43-5
2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde

: 1344996-01-5
1-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

2.1: sodium acetate / dichloromethane; methanol / 20 °C

2.2: 2 h / 20 °C

3.1: sodium hydroxide; water / isopropyl alcohol / 2 h / 90 °C

3.2: pH 3 - 4

With potassium phosphate; water; sodium acetate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 1.1: Suzuki Coupling;

Reference yield:

: 1334607-79-2
4,4,5,5-tetramethyl-2-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane

: 1344996-01-5
1-(2-ethyl-3-(5-(4-isopropoxy-3-(trifluoromethyl)phenyl)-1,2,4-thiadiazol-3-yl)benzyl)azetidine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium phosphate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 1 h / 80 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.75 h / 120 °C / Inert atmosphere; Microwave irradiation; Sealed vessel

3.1: sodium acetate / dichloromethane; methanol / 20 °C

3.2: 2 h / 20 °C

4.1: sodium hydroxide; water / isopropyl alcohol / 2 h / 90 °C

4.2: pH 3 - 4

With potassium phosphate; water; sodium acetate; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; 1.1: Suzuki Coupling / 2.1: Suzuki Coupling;