N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide

Base Information

• Chemical Name: N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide
• CAS No.: 1428858-65-4
• Molecular Formula: C₂₂H₁₆N₂O
• Molecular Weight: 324.382
• Mol file: 1428858-65-4.mol

Synonyms:N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide

Chemical Property of N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide

There total 6 articles about N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tert-butyl (3-bromobenzoyl)(quinolin-8-yl)carbamate + phenylboronic acid (98-80-6) → N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide (1428858-65-4)

Guidance literature:

tert-butyl (3-bromobenzoyl)(quinolin-8-yl)carbamate; phenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium acetate; In 1,4-dioxane; at 80 ℃; for 0.166667h; Microwave irradiation; Inert atmosphere;

With water; In 1,4-dioxane; at 120 ℃; for 0.133333h; Microwave irradiation; Inert atmosphere;

DOI:10.1021/acs.joc.6b01725

Reference yield: 65.0%

8-amino quinoline (578-66-5) + 3-phenylbenzoyl chloride (42498-44-2) → N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide (1428858-65-4)

Guidance literature:

8-amino quinoline; With dmap; triethylamine; In dichloromethane; for 0.0833333h; Inert atmosphere;

3-phenylbenzoyl chloride; In dichloromethane; Inert atmosphere;

DOI:10.1002/chem.202102734

Reference yield:

8-amino quinoline (578-66-5) + 3-phenylbenzoic acid (716-76-7) → N-(quinolin-8-yl)-[1,1′-biphenyl]-3-carboxamide (1428858-65-4)

Guidance literature:

3-phenylbenzoic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 5h; Reflux;

8-amino quinoline; With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.7b00442

upstream raw materials:

8-amino quinoline

3-phenylbenzoyl chloride

3-phenylbenzoic acid

3-bromo-1-(quinolin-8-yl)benzamide

Downstream raw materials:

N-(quinolin-8-yl)-[1,1':4',1-terphenyl]-2'-carboxamide

C₃₀H₂₅N₃O

C₂₉H₂₂N₂O₂

C₃₄H₂₄N₂O