carbonic acid 4-[2-(2-amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

Base Information

Chemical Name:carbonic acid 4-[2-(2-amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester
CAS No.:852446-53-8
Molecular Formula:C₂₁H₂₉N₃O₅S
Molecular Weight:435.544
Hs Code.:

carbonic acid 4-[2-(2-amino-thiazol-4-yl)-2-<i>tert</i>-butoxycarbonylamino-ethyl]-phenyl ester <i>tert</i>-butyl ester

Synonyms:carbonic acid 4-[2-(2-amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

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Chemical Property of carbonic acid 4-[2-(2-amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

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Technology Process of carbonic acid 4-[2-(2-amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

There total 4 articles about carbonic acid 4-[2-(2-amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 852446-53-8
carbonic acid 4-[2-(2-amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. KOH / propan-2-ol / pH 11.5 - 12.0

2.1: diisopropylethylamine; isobutyl chloroformate / tetrahydrofuran / cooling

2.2: tetrahydrofuran; various solvent(s)

3.1: aq. HBr; AcOH / ethyl acetate / -45 °C

4.1: acetonitrile / 24 h / Heating

With potassium hydroxide; hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; ethyl acetate; isopropyl alcohol; acetonitrile;
DOI:10.1021/jm040134d

Reference yield:

: 20866-48-2
(S)-2-(tert-butoxycarbonylamino)-3-(4-(tert-butoxycarbonyloxy)phenyl)propanoic acid

: 852446-53-8
carbonic acid 4-[2-(2-amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylethylamine; isobutyl chloroformate / tetrahydrofuran / cooling

1.2: tetrahydrofuran; various solvent(s)

2.1: aq. HBr; AcOH / ethyl acetate / -45 °C

3.1: acetonitrile / 24 h / Heating

With hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; ethyl acetate; acetonitrile;
DOI:10.1021/jm040134d

Reference yield:

: 390815-84-6
carbonic acid 4-((S)-2-tert-butoxycarbonylamino-4-diazo-3-oxo-butyl)-phenyl ester tert-butyl ester

: 852446-53-8
carbonic acid 4-[2-(2-amino-thiazol-4-yl)-2-tert-butoxycarbonylamino-ethyl]-phenyl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HBr; AcOH / ethyl acetate / -45 °C

2: acetonitrile / 24 h / Heating

With hydrogen bromide; acetic acid; In ethyl acetate; acetonitrile;
DOI:10.1021/jm040134d