Technology Process of 3-((1s,4r)-4-(4-Chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanal
There total 12 articles about 3-((1s,4r)-4-(4-Chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
citric acid;
In
dichloromethane; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: 96 percent / sodium tungstate dihydrate; sulfuric acid; hydrogen peroxide / aliquat 336 / H2O; toluene / 45 °C
2.1: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C
3.1: xylene / 16 h / 130 °C
4.1: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C
5.1: potassium tert-butoxide / tetrahydrofuran / 1 h / -5 °C
5.2: 97 percent / tetrahydrofuran / 20 h / 22 °C
6.1: 94 percent / L-selectride / tetrahydrofuran / 1.5 h / -60 °C
7.1: 96 percent / diisobutylaluminium hydride / toluene / 1 h / -40 °C
8.1: potassium tert-butoxide / tetrahydrofuran / cooling
8.2: tetrahydrofuran; toluene / -20 - 20 °C
9.1: 5.6 kg / aq. HCl / tetrahydrofuran; toluene; dimethylformamide / 2 h / 45 °C
With
hydrogenchloride; sodium tungstate; sulfuric acid; potassium tert-butylate; dihydrogen peroxide; acetic anhydride; L-Selectride; diisobutylaluminium hydride;
Aliquat 336;
In
tetrahydrofuran; water; N,N-dimethyl-formamide; toluene; xylene;
3.1: Diels-Alder reaction / 5.2: Horner-Wadsworth-Emmons olefination / 8.2: Wittig reaction;
DOI:10.1021/jo070407n
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 100 percent / sodium hydroxide / ethanol / cooling
2.1: 96 percent / sodium tungstate dihydrate; sulfuric acid; hydrogen peroxide / aliquat 336 / H2O; toluene / 45 °C
3.1: 92 percent / acetic anhydride / dimethylformamide / 24.5 h / 60 °C
4.1: xylene / 16 h / 130 °C
5.1: 110 g / aq. HCl / xylene; tetrahydrofuran / 2 h / 50 °C
6.1: potassium tert-butoxide / tetrahydrofuran / 1 h / -5 °C
6.2: 97 percent / tetrahydrofuran / 20 h / 22 °C
7.1: 94 percent / L-selectride / tetrahydrofuran / 1.5 h / -60 °C
8.1: 96 percent / diisobutylaluminium hydride / toluene / 1 h / -40 °C
9.1: potassium tert-butoxide / tetrahydrofuran / cooling
9.2: tetrahydrofuran; toluene / -20 - 20 °C
10.1: 5.6 kg / aq. HCl / tetrahydrofuran; toluene; dimethylformamide / 2 h / 45 °C
With
hydrogenchloride; sodium hydroxide; sodium tungstate; sulfuric acid; potassium tert-butylate; dihydrogen peroxide; acetic anhydride; L-Selectride; diisobutylaluminium hydride;
Aliquat 336;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene; xylene;
4.1: Diels-Alder reaction / 6.2: Horner-Wadsworth-Emmons olefination / 9.2: Wittig reaction;
DOI:10.1021/jo070407n