(E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene

Base Information

• Chemical Name: (E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene
• CAS No.: 179032-00-9
• Molecular Formula: C₂₃H₁₉F₃O₂
• Molecular Weight: 384.398
• Mol file: 179032-00-9.mol

Synonyms:(E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene

Chemical Property of (E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene

There total 2 articles about (E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

(1S,2S)-3,3,3-Trifluoro-1-[4-(2-methoxymethoxy-ethoxy)-phenyl]-1,2-diphenyl-propan-1-ol → (Z)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene + (E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene (179032-00-9)

Guidance literature:

With hydrogenchloride; In methanol; for 1h; Yield given. Title compound not separated from byproducts; Heating;

DOI:10.1016/0040-4020(96)00763-6

Reference yield:

3,3,3-trifluoro-1,2-diphenylpropan-1-one (154669-95-1) → (E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene (179032-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / tetrahydrofuran / 2 h / 0 - 5 °C

2: 84 percent / conc. aq. HCl / methanol / 1 h / Heating

With hydrogenchloride; In tetrahydrofuran; methanol;

DOI:10.1016/0040-4020(96)00763-6

Reference yield: 89.0%

(E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene (179032-00-9) → (E)-3,3,3-trifluoro-1-[4-(2-chloroethoxy)phenyl]-1,2-diphenylpropene (179031-96-0)

Guidance literature:

With pyridine; thionyl chloride; for 1h; Heating;

DOI:10.1016/0040-4020(96)00763-6

upstream raw materials:

3,3,3-trifluoro-1,2-diphenylpropan-1-one

Downstream raw materials:

(E)-3,3,3-trifluoro-1-[4-(2-chloroethoxy)phenyl]-1,2-diphenylpropene

(E)-3,3,3-trifluoro-1-{4-[2-(2-hydroxyethylamino)ethoxy]phenyl}-1,2-diphenylpropene