154669-95-1

Basic information

• Product Name: 3,3,3-trifluoro-1,2-diphenylpropan-1-one
• Synonyms: 3,3,3-trifluoro-1,2-diphenylpropan-1-one
• CAS NO: 154669-95-1
• Molecular Weight: 264.247
• Mol File: 154669-95-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 3,3,3-trifluoro-1,2-diphenylpropan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3,3,3-trifluoro-1,2-diphenylpropan-1-one(154669-95-1)
• EPA Substance Registry System: 3,3,3-trifluoro-1,2-diphenylpropan-1-one(154669-95-1)

Safety Data

• Hazardous Substances Data: 154669-95-1(Hazardous Substances Data)

Upstream product

• 588-59-0 stilbene 
• 4098-15-1 (1-azido-2-iodoethane-1,2-diyl)dibenzene 
• 61795-22-0 (1-azidoethene-1,2-diyl)dibenzene 
• 2926-29-6 Langlois reagent 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 887144-94-7 Togni's reagent II 
• 103-30-0 (E)-1,2-diphenyl-ethene 
• 451-40-1 phenyl benzyl ketone 
• 34544-89-3 (E,Z)-α-Acetoxystilbene 
• 421-83-0 trifluoromethane sulfonyl chloride 
• 51760-82-8 CF₃(Ph)CHC(O)Cl 
• 71-43-2 benzene 

Downstream Products

• 179032-00-9 (E)-3,3,3-trifluoro-1-[4-(2-hydroxyethoxy)phenyl]-1,2-diphenylpropene 
• 77599-17-8 (E)-3,3,3-trifluoro-1-{4-[2-(2-hydroxyethylamino)ethoxy]phenyl}-1,2-diphenylpropene 
• 179031-96-0 (E)-3,3,3-trifluoro-1-[4-(2-chloroethoxy)phenyl]-1,2-diphenylpropene 
• 36029-60-4 (E)-3,3,3-trifluoro-1-(4-methoxyphenyl)-1,2-diphenylpropene 
• 34288-92-1 (Z)-1-(4-methoxyphenyl)-1,2-diphenyl-3,3,3-trifluoropropene 

Relevant articles and documents

Photoredox-catalysed redox-neutral trifluoromethylation of vinyl azides for the synthesis of α-trifluoromethylated ketones

A redox-neutral, mild, and simple protocol is developed for the synthesis of α-trifluoromethylated ketones from vinyl azides under transition-metal-free conditions. In the presence of organic photoredox catalyst N-methyl-9-mesityl acridinium and sodium trifluoromethanesulfinate, a broad range of substituted vinyl azides were found to react smoothly upon visible-light irradiation, readily furnishing the corresponding products in satisfied yields.

Combining photoredox-catalyzed trifluoromethylation and oxidation with dmso: Facile synthesis of α-trifluoromethylated ketones from aromatic alkenes

Trifluoromethylated ketones are useful building blocks for organic compounds with a trifluoromethyl group. A new and facile synthesis of ketones with a trifluoromethyl substituent in the α-position proceeds through a one-pot photoredox-catalyzed trifluoromethylation-oxidation sequence of aromatic alkenes. Dimethyl sulfoxide (DMSO) serves as a key and mild oxidant under these photocatalytic conditions. Furthermore, an iridium photocatalyst, fac[Ir(ppy)3] (ppy=2-phenylpyridine), turned out to be crucial for the present photoredox process. Valuable α-CF3-substituted ketones can be synthesized from aromatic alkenes by combining photoredox-catalyzed trifluoromethylation and oxidation with DMSO. The iridium photocatalyst fac-[Ir(ppy)3] (ppy=2-phenylpyridine) plays key roles in this keto-trifluoromethylation. SET=single electron transfer.

Sulfonation and trifluoromethylation of enol acetates with sulfonyl chlorides using visible-light photoredox catalysis

A mild, practical method to prepare α-sulfonyl and α-trifluoromethyl ketones from readily available enol acetates and sulfonyl chlorides has been developed using visible-light photoredox catalysis. The method could be used with a wide range of enol acetates and sulfonyl chlorides, and gave the desired products in satisfactory to excellent yields. A practical method to prepare α-sulfonyl and α-trifluoromethyl ketones from enol acetates and sulfonyl chlorides using visible-light photoredox catalysis is presented. Copyright