Technology Process of benzhydryl 6α-ethynyl-6β-(trifluoromethanesulfonato)penicillinate
There total 4 articles about benzhydryl 6α-ethynyl-6β-(trifluoromethanesulfonato)penicillinate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 32 percent / 70percent HClO4, NaNO2 / H2O / 0.33 h / -5 - 0 °C
2: 42 percent / ethyl acetate; diethyl ether / 5 h / Ambient temperature
3: 97 percent / trifluoroacetic anhydride, dimethyl sulfoxide / CH2Cl2 / 1 h / -78 °C
5: 44 percent / pyridine / CHCl3 / Ambient temperature
With
pyridine; perchloric acid; dimethyl sulfoxide; trifluoroacetic anhydride; sodium nitrite;
In
diethyl ether; dichloromethane; chloroform; water; ethyl acetate;
DOI:10.1021/jo00058a008
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 42 percent / ethyl acetate; diethyl ether / 5 h / Ambient temperature
2: 97 percent / trifluoroacetic anhydride, dimethyl sulfoxide / CH2Cl2 / 1 h / -78 °C
4: 44 percent / pyridine / CHCl3 / Ambient temperature
With
pyridine; dimethyl sulfoxide; trifluoroacetic anhydride;
In
diethyl ether; dichloromethane; chloroform; ethyl acetate;
DOI:10.1021/jo00058a008
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 97 percent / trifluoroacetic anhydride, dimethyl sulfoxide / CH2Cl2 / 1 h / -78 °C
3: 44 percent / pyridine / CHCl3 / Ambient temperature
With
pyridine; dimethyl sulfoxide; trifluoroacetic anhydride;
In
dichloromethane; chloroform;
DOI:10.1021/jo00058a008
