(S,S)-7-[4-(benzyl)oxazol-2-yl]-7'-di(4-methoxyphenyl)phosphinyl-1,1'-spirobiindane

Base Information

Chemical Name:(S,S)-7-[4-(benzyl)oxazol-2-yl]-7'-di(4-methoxyphenyl)phosphinyl-1,1'-spirobiindane
CAS No.:913829-89-7
Molecular Formula:C₄₁H₃₈NO₃P
Molecular Weight:623.731
Hs Code.:

Synonyms:(S,S)-7-[4-(benzyl)oxazol-2-yl]-7'-di(4-methoxyphenyl)phosphinyl-1,1'-spirobiindane

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Chemical Property of (S,S)-7-[4-(benzyl)oxazol-2-yl]-7'-di(4-methoxyphenyl)phosphinyl-1,1'-spirobiindane

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Technology Process of (S,S)-7-[4-(benzyl)oxazol-2-yl]-7'-di(4-methoxyphenyl)phosphinyl-1,1'-spirobiindane

There total 5 articles about (S,S)-7-[4-(benzyl)oxazol-2-yl]-7'-di(4-methoxyphenyl)phosphinyl-1,1'-spirobiindane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 913829-84-2
(S,S)-N-(1-hydroxymethyl-2-methylbenzyl)-7'-di(4-methoxyphenyl)phosphino-1,1'-spirobiindane-7-carboxylamide

: 913829-89-7
(S,S)-7-[4-(benzyl)oxazol-2-yl]-7'-di(4-methoxyphenyl)phosphinyl-1,1'-spirobiindane

Guidance literature:: With 4-(Methylamino)pyridine; methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1021/ja063444p

Reference yield:

: C₃₂H₂₈O₅F₃PS

: 913829-89-7
(S,S)-7-[4-(benzyl)oxazol-2-yl]-7'-di(4-methoxyphenyl)phosphinyl-1,1'-spirobiindane

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / dppp / Pd(OAc)2 / dimethylsulfoxide; triethylamine / 70 °C

2: 67 percent / aq. KOH / methanol / 100 °C

3: 93 percent / HOBt; DCC / tetrahydrofuran / 20 °C

4: 76 percent / Et₃N; 4-methylaminopyridine; MeSO₂Cl / CH₂Cl₂ / 0 - 20 °C

With 4-(Methylamino)pyridine; potassium hydroxide; 1,3-bis-(diphenylphosphino)propane; benzotriazol-1-ol; methanesulfonyl chloride; triethylamine; dicyclohexyl-carbodiimide; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; triethylamine;
DOI:10.1021/ja063444p

Reference yield:

: 913829-79-5
(S)-7-di(4-methoxyphenyl)phosphino-7'-carboxy-1,1'-spirobiindane

: 913829-89-7
(S,S)-7-[4-(benzyl)oxazol-2-yl]-7'-di(4-methoxyphenyl)phosphinyl-1,1'-spirobiindane

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / HOBt; DCC / tetrahydrofuran / 20 °C

2: 76 percent / Et₃N; 4-methylaminopyridine; MeSO₂Cl / CH₂Cl₂ / 0 - 20 °C

With 4-(Methylamino)pyridine; benzotriazol-1-ol; methanesulfonyl chloride; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja063444p