(S,S)-N-(1-hydroxymethyl-2-methylbenzyl)-7'-di(4-methoxyphenyl)phosphino-1,1'-spirobiindane-7-carboxylamide

Base Information

Chemical Name:(S,S)-N-(1-hydroxymethyl-2-methylbenzyl)-7'-di(4-methoxyphenyl)phosphino-1,1'-spirobiindane-7-carboxylamide
CAS No.:913829-84-2
Molecular Formula:C₄₁H₄₀NO₄P
Molecular Weight:641.747
Hs Code.:

Synonyms:(S,S)-N-(1-hydroxymethyl-2-methylbenzyl)-7'-di(4-methoxyphenyl)phosphino-1,1'-spirobiindane-7-carboxylamide

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Chemical Property of (S,S)-N-(1-hydroxymethyl-2-methylbenzyl)-7'-di(4-methoxyphenyl)phosphino-1,1'-spirobiindane-7-carboxylamide

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Technology Process of (S,S)-N-(1-hydroxymethyl-2-methylbenzyl)-7'-di(4-methoxyphenyl)phosphino-1,1'-spirobiindane-7-carboxylamide

There total 3 articles about (S,S)-N-(1-hydroxymethyl-2-methylbenzyl)-7'-di(4-methoxyphenyl)phosphino-1,1'-spirobiindane-7-carboxylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 913829-79-5
(S)-7-di(4-methoxyphenyl)phosphino-7'-carboxy-1,1'-spirobiindane

: 3182-95-4
L-Phenylalaninol

: 913829-84-2
(S,S)-N-(1-hydroxymethyl-2-methylbenzyl)-7'-di(4-methoxyphenyl)phosphino-1,1'-spirobiindane-7-carboxylamide

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ja063444p

Reference yield:

: C₃₂H₂₈O₅F₃PS

: 913829-84-2
(S,S)-N-(1-hydroxymethyl-2-methylbenzyl)-7'-di(4-methoxyphenyl)phosphino-1,1'-spirobiindane-7-carboxylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / dppp / Pd(OAc)2 / dimethylsulfoxide; triethylamine / 70 °C

2: 67 percent / aq. KOH / methanol / 100 °C

3: 93 percent / HOBt; DCC / tetrahydrofuran / 20 °C

With potassium hydroxide; 1,3-bis-(diphenylphosphino)propane; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium diacetate; In tetrahydrofuran; methanol; dimethyl sulfoxide; triethylamine;
DOI:10.1021/ja063444p

Reference yield:

: 913829-76-2
(S)-7-di(4-methoxyphenyl)phosphino-7'-carbomethoxy-1,1'-spirobiindane

: 913829-84-2
(S,S)-N-(1-hydroxymethyl-2-methylbenzyl)-7'-di(4-methoxyphenyl)phosphino-1,1'-spirobiindane-7-carboxylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / aq. KOH / methanol / 100 °C

2: 93 percent / HOBt; DCC / tetrahydrofuran / 20 °C

With potassium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol;
DOI:10.1021/ja063444p