2-(4-(((1r,4r)-4-(dimethylamino)cyclohexyl)amino)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-5-yl)-1-(pyrrolidin-1-yl)ethanone

Base Information

Chemical Name:2-(4-(((1r,4r)-4-(dimethylamino)cyclohexyl)amino)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-5-yl)-1-(pyrrolidin-1-yl)ethanone
CAS No.:1388893-71-7
Molecular Formula:C₂₃H₃₃N₅OS
Molecular Weight:427.614
Hs Code.:

Synonyms:2-(4-(((1r,4r)-4-(dimethylamino)cyclohexyl)amino)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-5-yl)-1-(pyrrolidin-1-yl)ethanone

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Chemical Property of 2-(4-(((1r,4r)-4-(dimethylamino)cyclohexyl)amino)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-5-yl)-1-(pyrrolidin-1-yl)ethanone

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Technology Process of 2-(4-(((1r,4r)-4-(dimethylamino)cyclohexyl)amino)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-5-yl)-1-(pyrrolidin-1-yl)ethanone

There total 11 articles about 2-(4-(((1r,4r)-4-(dimethylamino)cyclohexyl)amino)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-5-yl)-1-(pyrrolidin-1-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 123-75-1
pyrrolidine

: 1388893-62-6
C₁₉H₂₆N₄O₂S

: 1388893-71-7
2-(4-(((1r,4r)-4-(dimethylamino)cyclohexyl)amino)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-5-yl)-1-(pyrrolidin-1-yl)ethanone

Guidance literature:: With triethylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1388893-59-1
C₁₉H₂₅N₅S

: 1388893-71-7
2-(4-(((1r,4r)-4-(dimethylamino)cyclohexyl)amino)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-5-yl)-1-(pyrrolidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / Cooling with ice

1.2: 16 h / 70 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 15 h / 20 °C

2.2: pH 5

3.1: triethylamine; HATU / N,N-dimethyl-formamide / 24 h / 20 °C

With thionyl chloride; water; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1019014-42-6
C₁₂H₁₁ClN₂O₂S

: 1388893-71-7
2-(4-(((1r,4r)-4-(dimethylamino)cyclohexyl)amino)-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-5-yl)-1-(pyrrolidin-1-yl)ethanone

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 55 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C

2.2: 2 h

3.1: thionyl chloride / 20 °C

4.1: dimethyl sulfoxide / 5 h / 70 °C

5.1: thionyl chloride / Cooling with ice

5.2: 16 h / 70 °C

6.1: sodium hydroxide; water / tetrahydrofuran; methanol / 15 h / 20 °C

6.2: pH 5

7.1: triethylamine; HATU / N,N-dimethyl-formamide / 24 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; water; potassium carbonate; triethylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; dimethyl sulfoxide; N,N-dimethyl-formamide;