N-hydroxy-7-(N-(4-(1-methyl-1H-indol-5-yl)phenyl)methylsulfonamido)heptanamide

Base Information

Chemical Name:N-hydroxy-7-(N-(4-(1-methyl-1H-indol-5-yl)phenyl)methylsulfonamido)heptanamide
CAS No.:1246375-05-2
Molecular Formula:C₂₃H₂₉N₃O₄S
Molecular Weight:443.567
Hs Code.:

Synonyms:N-hydroxy-7-(N-(4-(1-methyl-1H-indol-5-yl)phenyl)methylsulfonamido)heptanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-hydroxy-7-(N-(4-(1-methyl-1H-indol-5-yl)phenyl)methylsulfonamido)heptanamide

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Technology Process of N-hydroxy-7-(N-(4-(1-methyl-1H-indol-5-yl)phenyl)methylsulfonamido)heptanamide

There total 5 articles about N-hydroxy-7-(N-(4-(1-methyl-1H-indol-5-yl)phenyl)methylsulfonamido)heptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: C₂₅H₃₂N₂O₄S

: 1246375-05-2
N-hydroxy-7-(N-(4-(1-methyl-1H-indol-5-yl)phenyl)methylsulfonamido)heptanamide

Guidance literature:: With hydroxylamine; potassium hydroxide; In water; at 20 ℃; for 10.5h;

Reference yield:

: 106-40-1
4-bromo-aniline

: 1246375-05-2
N-hydroxy-7-(N-(4-(1-methyl-1H-indol-5-yl)phenyl)methylsulfonamido)heptanamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 20 °C

2: potassium carbonate / acetonitrile / 40 - 60 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 120 °C / Microwave irradiation

4: potassium carbonate / 20 °C

5: potassium hydroxide; hydroxylamine / water / 10.5 h / 20 °C

With hydroxylamine; potassium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; acetonitrile; 3: Suzuki Coupling;

Reference yield:

: 4284-50-8
N-(4-bromophenyl)methanesulfonamide

: 1246375-05-2
N-hydroxy-7-(N-(4-(1-methyl-1H-indol-5-yl)phenyl)methylsulfonamido)heptanamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetonitrile / 40 - 60 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; water / 120 °C / Microwave irradiation

3: potassium carbonate / 20 °C

4: potassium hydroxide; hydroxylamine / water / 10.5 h / 20 °C

With hydroxylamine; potassium carbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; water; acetonitrile; 2: Suzuki Coupling;