(4S)-4-Amino-1-[(4-methoxyphenyl)sulfonyl]-D-proline methyl ester

Base Information

Chemical Name:(4S)-4-Amino-1-[(4-methoxyphenyl)sulfonyl]-D-proline methyl ester
CAS No.:204072-63-9
Molecular Formula:C₁₃H₁₈N₂O₅S
Molecular Weight:314.362
Hs Code.:
DSSTox Substance ID:DTXSID201167978

Synonyms:DTXSID201167978;(4S)-4-Amino-1-[(4-methoxyphenyl)sulfonyl]-D-proline methyl ester;204072-63-9

Suppliers and Price of (4S)-4-Amino-1-[(4-methoxyphenyl)sulfonyl]-D-proline methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4S)-4-Amino-1-[(4-methoxyphenyl)sulfonyl]-D-proline methyl ester

Chemical Property:

XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:5
Exact Mass:314.09364285
Heavy Atom Count:21
Complexity:467

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=CC=C(C=C1)S(=O)(=O)N2CC(CC2C(=O)OC)N
Isomeric SMILES:COC1=CC=C(C=C1)S(=O)(=O)N2C[C@H](C[C@@H]2C(=O)OC)N

Technology Process of (4S)-4-Amino-1-[(4-methoxyphenyl)sulfonyl]-D-proline methyl ester

There total 6 articles about (4S)-4-Amino-1-[(4-methoxyphenyl)sulfonyl]-D-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 204072-62-8
1N-(4-methoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-azidopyrrolidine

: 204072-63-9
1N-(4-methoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-aminopyrrolidine

Guidance literature:: With formic acid; hydrogen; 10percent Pd/C; In tetrahydrofuran; ethanol; for 16h; under 2792.67 Torr;
DOI:10.1021/jm000246e

Reference yield:

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 204072-63-9
1N-(4-methoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-aminopyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N; DMAP / H₂O; dioxane / 14 h / 20 °C

2: SOCl₂ / 14 h

3: Et₃N / CH₂Cl₂ / 20 °C

4: 79 percent / NaN₃ / dimethylformamide / 26 h / 55 °C

5: 58 percent / H₂; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr

With dmap; formic acid; thionyl chloride; sodium azide; hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e

Reference yield:

: 2584-71-6,30724-02-8
cis-hydroxy-D-proline

: 204072-63-9
1N-(4-methoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-aminopyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N; DMAP / H₂O; dioxane / 14 h / 20 °C

2: SOCl₂ / 14 h

3: Et₃N / CH₂Cl₂ / 20 °C

4: 79 percent / NaN₃ / dimethylformamide / 26 h / 55 °C

5: 58 percent / H₂; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr

With dmap; formic acid; thionyl chloride; sodium azide; hydrogen; triethylamine; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e