3-(2,3-dichlorobenzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

Base Information

Chemical Name:3-(2,3-dichlorobenzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one
CAS No.:1374306-10-1
Molecular Formula:C₁₇H₁₇Cl₂N₅O₂S
Molecular Weight:426.326
Hs Code.:

Synonyms:3-(2,3-dichlorobenzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

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Chemical Property of 3-(2,3-dichlorobenzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

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Technology Process of 3-(2,3-dichlorobenzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

There total 3 articles about 3-(2,3-dichlorobenzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 110-91-8,99108-56-2
morpholine

: 1374306-32-7
C₁₃H₉Cl₃N₄OS

: 1374306-10-1
3-(2,3-dichlorobenzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

Guidance literature:: In ethanol; at 150 ℃; for 1h; Microwave irradiation;
DOI:10.1016/j.bmcl.2012.03.039

Reference yield:

: 1374306-27-0
C₆H₄Cl₂N₄S

: 1374306-10-1
3-(2,3-dichlorobenzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / 0.75 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

3: ethanol / 1 h / 150 °C / Microwave irradiation

With potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.039

Reference yield:

: 1374306-29-2
C₆H₅ClN₄OS

: 57915-78-3
1-(bromomethyl)-2,3-dichlorobenzene

: 1374306-10-1
3-(2,3-dichlorobenzyl)-2-(methylthio)-5-morpholino-[1,2,4]triazolo[1,5-a]pyrimidin-7(3H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 120 °C / Microwave irradiation

2: ethanol / 1 h / 150 °C / Microwave irradiation

With potassium carbonate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.03.039