1-(2,2-diethoxyethyl)-1-[(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea

Base Information

Chemical Name:1-(2,2-diethoxyethyl)-1-[(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea
CAS No.:377078-88-1
Molecular Formula:C₂₆H₃₁F₂N₉O₄
Molecular Weight:571.587
Hs Code.:

Synonyms:1-(2,2-diethoxyethyl)-1-[(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(2,2-diethoxyethyl)-1-[(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-(2,2-diethoxyethyl)-1-[(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea

There total 10 articles about 1-(2,2-diethoxyethyl)-1-[(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 217654-45-0
phenyl 4-(1H-1-tetrazolyl)phenylcarbamate

: 377078-85-8
(2S,3R)-3-(2,2-diethoxyethyl)amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 377078-88-1
1-(2,2-diethoxyethyl)-1-[(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea

Guidance literature:: In N,N-dimethyl-formamide; at 80 ℃; for 6h;
DOI:10.1248/cpb.49.1110

Reference yield:

: 138373-69-0
(1S)-1-<(2S)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol

: 377078-88-1
1-(2,2-diethoxyethyl)-1-[(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea

Guidance literature:: Multi-step reaction with 6 steps

1.1: 68 percent / PPh₃; diethyl azodicarboxylate / tetrahydrofuran / 1 h / 20 °C

2.1: 87 percent / NaOMe / methanol / 20 °C

3.1: acetic acid / 0.5 h / 20 °C

4.1: NaH / dimethylformamide / 0.17 h / 0 °C

4.2: dimethylformamide / 5.5 h / 50 °C

5.1: 72 percent / Ti(O-isoPr)4 / propan-1-ol / 5.5 h / Heating

6.1: 82 percent / dimethylformamide / 6 h / 80 °C

With titanium(IV) isopropylate; sodium methylate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; propan-1-ol; acetic acid; N,N-dimethyl-formamide; 1.1: Mitsunobu reaction;
DOI:10.1248/cpb.49.1110

Reference yield:

: 150802-86-1
(1R)-1-<(2S)-2-(2,4-difluorophenyl)-2-oxiranyl>ethanol

: 377078-88-1
1-(2,2-diethoxyethyl)-1-[(1R,2S)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / 0.5 h / 20 °C

2.1: NaH / dimethylformamide / 0.17 h / 0 °C

2.2: dimethylformamide / 5.5 h / 50 °C

3.1: 72 percent / Ti(O-isoPr)4 / propan-1-ol / 5.5 h / Heating

4.1: 82 percent / dimethylformamide / 6 h / 80 °C

With titanium(IV) isopropylate; sodium hydride; In propan-1-ol; acetic acid; N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.1110