5'-O-[[[(1S)-2-methoxy-1-methyl-2-oxoethyl]amino][4-(trifluoromethyl)phenoxy]phosphinyl]-2'-C-methylcytidine

Base Information

Chemical Name:5'-O-[[[(1S)-2-methoxy-1-methyl-2-oxoethyl]amino][4-(trifluoromethyl)phenoxy]phosphinyl]-2'-C-methylcytidine
CAS No.:946511-32-6
Molecular Formula:C₂₁H₂₆F₃N₄O₉P
Molecular Weight:566.428
Hs Code.:

Synonyms:5'-O-[[[(1S)-2-methoxy-1-methyl-2-oxoethyl]amino][4-(trifluoromethyl)phenoxy]phosphinyl]-2'-C-methylcytidine

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Chemical Property of 5'-O-[[[(1S)-2-methoxy-1-methyl-2-oxoethyl]amino][4-(trifluoromethyl)phenoxy]phosphinyl]-2'-C-methylcytidine

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Technology Process of 5'-O-[[[(1S)-2-methoxy-1-methyl-2-oxoethyl]amino][4-(trifluoromethyl)phenoxy]phosphinyl]-2'-C-methylcytidine

There total 2 articles about 5'-O-[[[(1S)-2-methoxy-1-methyl-2-oxoethyl]amino][4-(trifluoromethyl)phenoxy]phosphinyl]-2'-C-methylcytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 247574-58-9
4-(trifluoromethyl)-phenyl-(methoxy-L-alaninyl)-phosphorochloridate

: 20724-73-6,115494-60-5
2'-C-methylcytidine

: 946511-32-6
5'-O-[[[(1S)-2-methoxy-1-methyl-2-oxoethyl]amino][4-(trifluoromethyl)phenoxy]phosphinyl]-2'-C-methylcytidine

Guidance literature:: 2'-C-methylcytidine; With tert-butylmagnesium chloride; In tetrahydrofuran; at -78 - 0 ℃; Inert atmosphere;

4-(trifluoromethyl)-phenyl-(methoxy-L-alaninyl)-phosphorochloridate; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm900447q