(R_P)-[2-(S)-(2-methoxymethylpyrrolidino)phenyl](2-methoxy-phenyl)(phenyl) phosphine oxide

Base Information

• Chemical Name: (R_P)-[2-(S)-(2-methoxymethylpyrrolidino)phenyl](2-methoxy-phenyl)(phenyl) phosphine oxide
• CAS No.: 896462-23-0
• Molecular Formula: C₂₅H₂₈NO₃P
• Molecular Weight: 421.476

Synonyms:(R_P)-[2-(S)-(2-methoxymethylpyrrolidino)phenyl](2-methoxy-phenyl)(phenyl) phosphine oxide

Chemical Property of (R_P)-[2-(S)-(2-methoxymethylpyrrolidino)phenyl](2-methoxy-phenyl)(phenyl) phosphine oxide

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Technology Process of (R_P)-[2-(S)-(2-methoxymethylpyrrolidino)phenyl](2-methoxy-phenyl)(phenyl) phosphine oxide

There total 4 articles about (R_P)-[2-(S)-(2-methoxymethylpyrrolidino)phenyl](2-methoxy-phenyl)(phenyl) phosphine oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

bis(2-methoxyphenyl)(phenyl) phosphine oxide (36712-28-4) + (2S)-2-(methoxymethyl)-1-pyrrolidine (63126-47-6) → (RP)-[2-(S)-(2-methoxymethylpyrrolidino)phenyl](2-methoxy-phenyl)(phenyl) phosphine oxide (896462-23-0) + (SP)-[2-(S)-(2-methoxymethylpyrrolidino)phenyl](2-methoxy-phenyl)(phenyl) phosphine oxide (896462-21-8) + bis[2-(S)-(2-methoxymethylpyrrolidino)phenyl](phenyl) phosphine oxide (896462-17-2)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tetasy.2006.03.010

Reference yield:

bis-(2-methoxy-phenyl)-phenyl-phosphane (36802-41-2) → (RP)-[2-(S)-(2-methoxymethylpyrrolidino)phenyl](2-methoxy-phenyl)(phenyl) phosphine oxide (896462-23-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / hydrogen peroxide / acetone / 1 h

2: 21 percent / n-BuLi / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; dihydrogen peroxide; In tetrahydrofuran; acetone;

DOI:10.1016/j.tetasy.2006.03.010

Reference yield:

Dichlorophenylphosphine (644-97-3) → (RP)-[2-(S)-(2-methoxymethylpyrrolidino)phenyl](2-methoxy-phenyl)(phenyl) phosphine oxide (896462-23-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: TMEDA; n-BuLi / diethyl ether; hexane / 2 h / 20 °C

1.2: 94 percent / diethyl ether; hexane / 0.5 h

2.1: 90 percent / hydrogen peroxide / acetone / 1 h

3.1: 21 percent / n-BuLi / tetrahydrofuran / -78 - 20 °C

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; dihydrogen peroxide; In tetrahydrofuran; diethyl ether; hexane; acetone;

DOI:10.1016/j.tetasy.2006.03.010

upstream raw materials:

bis(2-methoxyphenyl)(phenyl) phosphine oxide

(2S)-2-(methoxymethyl)-1-pyrrolidine

bis-(2-methoxy-phenyl)-phenyl-phosphane

methoxybenzene

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