(S)-tert-butyl (1-((4-fluoro-2-((3-fluorophenyl)amino)phenyl)amino)-1-oxopropan-2-yl)carbamate

Base Information

Chemical Name:(S)-tert-butyl (1-((4-fluoro-2-((3-fluorophenyl)amino)phenyl)amino)-1-oxopropan-2-yl)carbamate
CAS No.:1338482-36-2
Molecular Formula:C₂₀H₂₃F₂N₃O₃
Molecular Weight:391.418
Hs Code.:

Synonyms:(S)-tert-butyl (1-((4-fluoro-2-((3-fluorophenyl)amino)phenyl)amino)-1-oxopropan-2-yl)carbamate

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Chemical Property of (S)-tert-butyl (1-((4-fluoro-2-((3-fluorophenyl)amino)phenyl)amino)-1-oxopropan-2-yl)carbamate

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Technology Process of (S)-tert-butyl (1-((4-fluoro-2-((3-fluorophenyl)amino)phenyl)amino)-1-oxopropan-2-yl)carbamate

There total 6 articles about (S)-tert-butyl (1-((4-fluoro-2-((3-fluorophenyl)amino)phenyl)amino)-1-oxopropan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 15761-38-3
L-N-Boc-Ala

: 1248596-90-8
5-fluoro-N₁-(3-fluorophenyl)benzene-1,2-diamine

: 1338482-36-2
(S)-tert-butyl (1-((4-fluoro-2-((3-fluorophenyl)amino)phenyl)amino)-1-oxopropan-2-yl)carbamate

Guidance literature:: L-N-Boc-Ala; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at -10 ℃; for 1h;

5-fluoro-N₁-(3-fluorophenyl)benzene-1,2-diamine; In dichloromethane; at -10 - 24 ℃; for 24.66h;
DOI:10.1021/acs.jmedchem.5b01651

Reference yield:

: 15761-38-3
L-N-Boc-Ala

: 1248596-90-8
5-fluoro-N₁-(3-fluorophenyl)benzene-1,2-diamine

: 1338482-36-2
(S)-tert-butyl (1-((4-fluoro-2-((3-fluorophenyl)amino)phenyl)amino)-1-oxopropan-2-yl)carbamate

: 1393178-80-7
{(S)-1-[6-fluoro-1-(3-fluorophenyl)-1H-benzoimidazol-2-yl]ethyl}carbamic acid tert-butyl ester

Guidance literature:: L-N-Boc-Ala; 5-fluoro-N₁-(3-fluorophenyl)benzene-1,2-diamine; With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water;

Reference yield:

: 446-35-5
2,4-Difluoronitrobenzene

: 1338482-36-2
(S)-tert-butyl (1-((4-fluoro-2-((3-fluorophenyl)amino)phenyl)amino)-1-oxopropan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -70 °C / Inert atmosphere

1.2: -70 - 20 °C

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 20 °C

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 20 °C / Inert atmosphere

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; dichloromethane; ethyl acetate;