3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-((2-methylamino)pyridin-5-yl)methyl)methyl-2-nitrothiophene

Base Information

Chemical Name:3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-((2-methylamino)pyridin-5-yl)methyl)methyl-2-nitrothiophene
CAS No.:1196072-06-6
Molecular Formula:C₂₂H₂₄Cl₂N₄O₅S₂
Molecular Weight:559.494
Hs Code.:

Synonyms:3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-((2-methylamino)pyridin-5-yl)methyl)methyl-2-nitrothiophene

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Chemical Property of 3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-((2-methylamino)pyridin-5-yl)methyl)methyl-2-nitrothiophene

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Technology Process of 3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-((2-methylamino)pyridin-5-yl)methyl)methyl-2-nitrothiophene

There total 9 articles about 3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-((2-methylamino)pyridin-5-yl)methyl)methyl-2-nitrothiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 897951-48-3
(6-(methylamino)pyridin-3-yl)methanol

: 1196071-97-2
TH-1152

: 1196072-06-6
3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-((2-methylamino)pyridin-5-yl)methyl)methyl-2-nitrothiophene

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; for 0.166667h;

Reference yield:

: 6373-46-2
p-benzyloxyaniline

: 1196072-06-6
3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-((2-methylamino)pyridin-5-yl)methyl)methyl-2-nitrothiophene

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid / water / -78 - 20 °C

2: trichlorophosphate / 1 h / 100 °C

3: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water; ethyl acetate / 3 h

4: triethylamine / dichloromethane / 0 - 20 °C

5: potassium tert-butylate / tetrahydrofuran; dichloromethane / 1 h / -50 °C

6: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.17 h

With hydrogenchloride; di-isopropyl azodicarboxylate; potassium tert-butylate; hydrogen; acetic acid; triethylamine; triphenylphosphine; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; 6: Mitsunobu reaction;

Reference yield:

: 101582-69-8
4--O-benzylphenol

: 1196072-06-6
3-(4-(N,N-bis-(2-chloroethyl)amino)phenoxysulfonyl-((2-methylamino)pyridin-5-yl)methyl)methyl-2-nitrothiophene

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 1 h / 100 °C

2: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water; ethyl acetate / 3 h

3: triethylamine / dichloromethane / 0 - 20 °C

4: potassium tert-butylate / tetrahydrofuran; dichloromethane / 1 h / -50 °C

5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0.17 h

With hydrogenchloride; di-isopropyl azodicarboxylate; potassium tert-butylate; hydrogen; triethylamine; triphenylphosphine; trichlorophosphate; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; 5: Mitsunobu reaction;