101582-69-8Relevant articles and documents
HYPOXIA ACTIVATED DRUGS OF NITROGEN MUSTARD ALKYLATORS
-
, (2009/12/23)
Hypoxia activated drug compounds having a structure of formula(I) are useful in the treatment of cancer and other hyperproliferative diseases.
Methods of chemical systhesis of phenolic nitrogen mustard prodrugs
-
, (2008/06/13)
This invention pertains to novel methods for the synthesis of certain nitrogen mustard prodrugs, such as N-[4-[N,N-bis(2-haloethylamino)-phenoxycarbonyl]-L-glutamic acid: wherein: X2 is a halo group, and is —F, —Cl, —Br, or —I; n is an integer
Melanocyte-directed enzyme prodrug therapy (MDEPT): Development of a targeted treatment for malignant melanoma
Jordan, Allan M.,Khan, Tariq H.,Osborn, Helen M. I.,Photiou, Andrew,Riley, Patrick A.
, p. 1775 - 1780 (2007/10/03)
A novel prodrug rationally designed to function as a tyrosinase substrate has been synthesised to allow targeted treatment of malignant melanoma. This agent has been evaluated for tyrosinase-mediated drug release, and has been shown to act in the desired