5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

Base Information

• Chemical Name: 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine
• CAS No.: 1455429-77-2
• Molecular Formula: C₃₄H₃₄N₂O₉
• Molecular Weight: 614.652
• Mol file: 1455429-77-2.mol

Synonyms:5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

Chemical Property of 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

There total 5 articles about 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

5'-O-levulinoyl-β-D-uridine (96026-63-0) + mono-4-methoxytrityl chloride (14470-28-1) → 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine (1455429-77-2) + 5'-O-levulinyl 3'-O-monomethoxytrityl ribouridine (1455429-79-4)

Guidance literature:

With pyridine; at 22 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.bmcl.2013.08.033

Reference yield:

levulinic acid (123-76-2) → 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine (1455429-77-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / dichloromethane; diethyl ether / 5 h / 22 °C / Inert atmosphere

2: Novozyme^? 435 / 1,4-dioxane / 22 °C / Inert atmosphere; Enzymatic reaction

3: pyridine / 3 h / 22 °C / Inert atmosphere

With pyridine; dicyclohexyl-carbodiimide; In 1,4-dioxane; diethyl ether; dichloromethane;

DOI:10.1016/j.bmcl.2013.08.033

Reference yield:

levulinic anhydride (40608-06-8) → 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine (1455429-77-2)

Guidance literature:

Multi-step reaction with 2 steps

1: Novozyme^? 435 / 1,4-dioxane / 22 °C / Inert atmosphere; Enzymatic reaction

2: pyridine / 3 h / 22 °C / Inert atmosphere

With pyridine; In 1,4-dioxane;

DOI:10.1016/j.bmcl.2013.08.033

upstream raw materials:

5'-O-levulinoyl-β-D-uridine

mono-4-methoxytrityl chloride

levulinic acid

levulinic anhydride

Downstream raw materials:

5'-O-levulinyl 2'-O-monomethoxytrityl 3'-O-phosphoramidous ribouridine