5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

Base Information

Chemical Name:5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine
CAS No.:1455429-77-2
Molecular Formula:C₃₄H₃₄N₂O₉
Molecular Weight:614.652
Hs Code.:

Synonyms:5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

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Technology Process of 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

There total 5 articles about 5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 96026-63-0
5'-O-levulinoyl-β-D-uridine

: 14470-28-1
mono-4-methoxytrityl chloride

: 1455429-77-2
5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

: 1455429-79-4
5'-O-levulinyl 3'-O-monomethoxytrityl ribouridine

Guidance literature:: With pyridine; at 22 ℃; for 3h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.08.033

Reference yield:

: 123-76-2
levulinic acid

: 1455429-77-2
5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / dichloromethane; diethyl ether / 5 h / 22 °C / Inert atmosphere

2: Novozyme^? 435 / 1,4-dioxane / 22 °C / Inert atmosphere; Enzymatic reaction

3: pyridine / 3 h / 22 °C / Inert atmosphere

With pyridine; dicyclohexyl-carbodiimide; In 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1016/j.bmcl.2013.08.033

Reference yield:

: 40608-06-8
levulinic anhydride

: 1455429-77-2
5'-O-levulinyl 2'-O-monomethoxytrityl ribouridine

Guidance literature:: Multi-step reaction with 2 steps

1: Novozyme^? 435 / 1,4-dioxane / 22 °C / Inert atmosphere; Enzymatic reaction

2: pyridine / 3 h / 22 °C / Inert atmosphere

With pyridine; In 1,4-dioxane;
DOI:10.1016/j.bmcl.2013.08.033