(+/-)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-3-(1-methylcyclobutyl)propanoate

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Chemical Name:(+/-)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-3-(1-methylcyclobutyl)propanoate
CAS No.:1422052-25-2
Molecular Formula:C₂₇H₂₇F₂N₅O₄S
Molecular Weight:555.605
Hs Code.:

Synonyms:(+/-)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-3-(1-methylcyclobutyl)propanoate

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Chemical Property of (+/-)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-3-(1-methylcyclobutyl)propanoate

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Technology Process of (+/-)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-3-(1-methylcyclobutyl)propanoate

There total 12 articles about (+/-)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-3-(1-methylcyclobutyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1259279-57-6
5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1422052-24-1
(+/-)-methyl 3-((2-chloro-5-fluoropyrimidin-4-yl)amino)-3-(1-methylcyclobutyl)propanoate

: 1422052-25-2
(+/-)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-3-(1-methylcyclobutyl)propanoate

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 2-methyltetrahydrofuran; water; Inert atmosphere; Sealed tube;
DOI:10.1021/acsmedchemlett.6b00486

Reference yield:

: 1417421-99-8
3-bromo-5-fluoro-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

: 1422052-25-2
(+/-)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-3-(1-methylcyclobutyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium acetate / water; 1,4-dioxane / 0.5 h / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: potassium phosphate / 2-methyltetrahydrofuran; water / 0.75 h / Inert atmosphere

2.2: 2 h / 115 °C / Sealed tube

With potassium phosphate; potassium acetate; In 2-methyltetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 1422052-25-2
(+/-)-methyl 3-((5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl)amino)-3-(1-methylcyclobutyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: potassium acetate / water; 1,4-dioxane / 0.5 h / Inert atmosphere

2.2: Inert atmosphere; Reflux

3.1: potassium phosphate / 2-methyltetrahydrofuran; water / 0.75 h / Inert atmosphere

3.2: 2 h / 115 °C / Sealed tube

With potassium phosphate; potassium acetate; sodium hydride; In 2-methyltetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;