5-Fluoro-1-tosyl-7-azaindole-3-boronic acid pinacol ester

Base Information

• Chemical Name: 5-Fluoro-1-tosyl-7-azaindole-3-boronic acid pinacol ester
• CAS No.: 1259279-57-6
• Molecular Formula: C20H24BFN2O5S
• Molecular Weight: 416.281
• Mol file: 1259279-57-6.mol

Synonyms:5-Fluoro-1-tosyl-7-azaindole-3-boronic acid pinacol ester;5-fluoro-1-(p-tolylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrolo[2,3-b]pyridine;1H-Pyrrolo[2,3-b]pyridine, 5-fluoro-1-[(4-methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;5-Fluoro-1-[(4-methylphenyl)sulfonyl]-7-azaindole-3-boronic acid pinacol ester;5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine

Chemical Property of 5-Fluoro-1-tosyl-7-azaindole-3-boronic acid pinacol ester

Chemical Property:

• Vapor Pressure: 0-0Pa at 20-25℃
• Boiling Point: 574.5±60.0 °C(Predicted)
• PKA: -1.05±0.30(Predicted)
• PSA: 78.80000
• Density: 1.28±0.1 g/cm3(Predicted)
• LogP: 4.10080

Purity/Quality:

99.9% ^*data from raw suppliers

5-Fluoro-1-tosyl-7-azaindole-3-boronicacidpinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Fluoro-1-tosyl-7-azaindole-3-boronic acid pinacol ester

There total 10 articles about 5-Fluoro-1-tosyl-7-azaindole-3-boronic acid pinacol ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-bromo-5-fluoro-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (1417421-99-8) + bis(pinacol)diborane (73183-34-3) → 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (1259279-57-6)

Guidance literature:

With potassium acetate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; at 100 ℃; for 15h; Inert atmosphere; Large scale;

Reference yield: 79.6%

5-fluoro-1-tosyl-1H-pyrrolo [2,3-b]pyridine (866318-99-2) + bis(pinacol)diborane (73183-34-3) → 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (1259279-57-6)

Guidance literature:

With (1,5-cyclooctadiene)(methoxy)iridium(I) dimer; 1,2-bis-(diphenylphosphino)ethane; In n-heptane; at 95 ℃; for 53h; Inert atmosphere;

Reference yield:

3-bromo-5-fluoro-1H-pyrrolo-[2,3-b]pyridine (1190309-71-7) → 5-fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine (1259279-57-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.17 h / 0 °C

1.2: 2 h / 0 - 20 °C

2.1: potassium acetate / water; 1,4-dioxane / 0.5 h / Inert atmosphere

2.2: Inert atmosphere; Reflux

With potassium acetate; sodium hydride; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

3-bromo-5-fluoro-1-(p-toluenesulfonyl)-1H-pyrrolo[2,3-b]pyridine

bis(pinacol)diborane

p-toluenesulfonyl chloride

3-bromo-5-fluoro-1H-pyrrolo-[2,3-b]pyridine

Downstream raw materials:

2-((1S,3S)-3-(5-fluoro-2-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-ylamino)-1-hydroxycyclohexyl)ethanenitrile

5-fluoro-1-tosyl-3-(3,5,6-trifluoropyridin-2-yl)-1H-pyrrolo[2,3-b]pyridine

tert-butyl ((1R,3S)-3-((5-cyano-3-fluoro-6-(5-fluoro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-yl)amino)cyclohexyl)carbamate