5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole

Base Information

• Chemical Name: 5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole
• CAS No.: 223757-42-4
• Molecular Formula: C₂₇H₃₁N₃O₆S
• Molecular Weight: 525.626
• Mol file: 223757-42-4.mol

Synonyms:5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole

Chemical Property of 5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole

There total 8 articles about 5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide (223757-44-6) → 5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole (223757-42-4)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; hexane; for 5h; Heating;

DOI:10.1021/jo9819382

Reference yield:

4-methoxymethoxy-benzaldehyde (6515-21-5) → 5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole (223757-42-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent

2: 50 percent / H₂ / Pd/C

3: 1.) PPh₃ / 1.) Et₂O, room temperature, 12 h, 2.) Et₂O, room temperature, 1 h, 2.) Et₂O, room temperature, 12 h

4: 76 percent / DIBAL / tetrahydrofuran; hexane / 5 h / Heating

With hydrogen; diisobutylaluminium hydride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; hexane;

DOI:10.1021/jo9819382

Reference yield:

4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → 5-hydroxy-4-(4-methoxybenzyl)-1-(4-methoxymethylenoxy)benzyl-2-tosylamino-4,5-dihydroimidazole (223757-42-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / NaH

2: 88 percent

3: 50 percent / H₂ / Pd/C

4: 1.) PPh₃ / 1.) Et₂O, room temperature, 12 h, 2.) Et₂O, room temperature, 1 h, 2.) Et₂O, room temperature, 12 h

5: 76 percent / DIBAL / tetrahydrofuran; hexane / 5 h / Heating

With hydrogen; sodium hydride; diisobutylaluminium hydride; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; hexane;

DOI:10.1021/jo9819382

upstream raw materials:

N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-5-oxo-4,5-dihydro-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide

4-methoxymethoxy-benzaldehyde

3-(4-methoxyphenyl)propanoic acid

ethyl 3-(4-methoxyphenyl)propanoate

Downstream raw materials:

N-[4-(4-methoxy-benzyl)-1-(4-methoxymethoxy-benzyl)-1H-imidazol-2-yl]-4-methyl-benzenesulfonamide

1,4-bis(4-hydroxybenzyl)-2-tosylaminoimidazole

4-[2-amino-1-(4-hydroxybenzyl)-1H-imidazol-4-ylmethyl]phenol