1-(1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-yl)-3-(propan-2-yl)urea

Base Information

• Chemical Name: 1-(1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-yl)-3-(propan-2-yl)urea
• CAS No.: 1416320-53-0
• Molecular Formula: C₂₆H₂₈Cl₃N₅O₂
• Molecular Weight: 548.9

Synonyms:1-(1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-yl)-3-(propan-2-yl)urea

Chemical Property of 1-(1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-yl)-3-(propan-2-yl)urea

Chemical Property:

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Technology Process of 1-(1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-yl)-3-(propan-2-yl)urea

There total 4 articles about 1-(1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-yl)-3-(propan-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-amine (1416320-52-9) + Isopropyl isocyanate (1795-48-8) → 1-(1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-yl)-3-(propan-2-yl)urea (1416320-53-0)

Guidance literature:

With triethylamine; In dichloromethane; for 16h;

Reference yield:

(piperidin-4-yl)carbamic acid tert-butyl ester (73874-95-0) → 1-(1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-yl)-3-(propan-2-yl)urea (1416320-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / 16 h

2: trifluoroacetic acid / dichloromethane / 4 h

3: triethylamine / dichloromethane / 16 h

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane;

Reference yield:

rimonabant acid (162758-35-2) → 1-(1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-yl)-3-(propan-2-yl)urea (1416320-53-0)

Guidance literature:

Multi-step reaction with 3 steps

1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine / 16 h

2: trifluoroacetic acid / dichloromethane / 4 h

3: triethylamine / dichloromethane / 16 h

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane;

upstream raw materials:

1-{[5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}piperidin-4-amine

Isopropyl isocyanate

rimonabant acid

(piperidin-4-yl)carbamic acid tert-butyl ester

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