Technology Process of O-methylarnottianamide
There total 8 articles about O-methylarnottianamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;
for 144h;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / CaCO3 / methanol / 40 °C / 30 h syringe drive, then 10 h
2: 1.) Amberlyst 15, 2.) 2.5 M NaOH / 1.) THF-H2O, 37 deg C, 16 h, 2.) MeOH-H2O, reflux, 5 min
3: Cr2O3, H2SO4 / acetone / 6 h / 0 °C
4: diphenylphosphoryl azide, Et3N / toluene / 15 h / Heating
5: LiAlH4 / tetrahydrofuran / 8 h / Heating
6: CHCl3 / 0 deg C -> RT, 4 h, then reflux 2 h
With
chromium(III) oxide; sodium hydroxide; lithium aluminium tetrahydride; Amberlyst 15; sulfuric acid; diphenylphosphoranyl azide; triethylamine; calcium carbonate;
In
tetrahydrofuran; methanol; chloroform; acetone; toluene;
DOI:10.1021/ja00341a059
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90 percent / CaCO3 / methanol / 40 °C / 30 h syringe drive, then 10 h
2: 1.) Amberlyst 15, 2.) 2.5 M NaOH / 1.) THF-H2O, 37 deg C, 16 h, 2.) MeOH-H2O, reflux, 5 min
3: Cr2O3, H2SO4 / acetone / 6 h / 0 °C
4: diphenylphosphoryl azide, Et3N / toluene / 15 h / Heating
5: LiAlH4 / tetrahydrofuran / 8 h / Heating
6: CHCl3 / 0 deg C -> RT, 4 h, then reflux 2 h
With
chromium(III) oxide; sodium hydroxide; lithium aluminium tetrahydride; Amberlyst 15; sulfuric acid; diphenylphosphoranyl azide; triethylamine; calcium carbonate;
In
tetrahydrofuran; methanol; chloroform; acetone; toluene;
DOI:10.1021/ja00341a059
