3-(3-(cyclopropanecarboxamido)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

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Chemical Name:3-(3-(cyclopropanecarboxamido)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide
CAS No.:1334419-82-7
Molecular Formula:C₂₆H₂₂F₃N₅O₂
Molecular Weight:493.488
Hs Code.:

Synonyms:3-(3-(cyclopropanecarboxamido)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

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Chemical Property of 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

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Technology Process of 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

There total 4 articles about 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1334419-94-1
3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

: 1334419-82-7
3-(3-(cyclopropanecarboxamido)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: 3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 2h;

Reference yield:

: 404827-77-6
ethyl 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-yl)benzoate

: 1334419-82-7
3-(3-(cyclopropanecarboxamido)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 4 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 0 °C

3.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / tert-butyl alcohol / 100 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.2: 2 h / 20 °C

With pyridine; sodium hydride; potassium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 1334419-88-3
N-(6-bromo-1H-indazol-3-yl)cyclopropanecarboxamide

: 1334419-82-7
3-(3-(cyclopropanecarboxamido)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 0 °C

2.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / tert-butyl alcohol / 100 °C / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.2: 2 h / 20 °C

With sodium hydride; potassium carbonate; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In dichloromethane; N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;