3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

Base Information

Chemical Name:3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide
CAS No.:1334419-94-1
Molecular Formula:C₃₂H₃₆F₃N₅O₃Si
Molecular Weight:623.75
Hs Code.:

Synonyms:3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

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Chemical Property of 3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

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Technology Process of 3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

There total 4 articles about 3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 23410-19-7
3-amino-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

: 1334419-93-0
N-(6-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-yl)cyclopropanecarboxamide

: 1334419-94-1
3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In tert-butyl alcohol; at 100 ℃; Inert atmosphere;

Reference yield:

: 404827-77-6
ethyl 3-(3-(cyclopropanecarboxamido)-1H-indazol-6-yl)benzoate

: 1334419-94-1
3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 4 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 0 °C

3.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / tert-butyl alcohol / 100 °C / Inert atmosphere

With pyridine; sodium hydride; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;

Reference yield:

: 1334419-88-3
N-(6-bromo-1H-indazol-3-yl)cyclopropanecarboxamide

: 1334419-94-1
3-(3-(cyclopropanecarboxamido)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-6-ylamino)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 0 °C

2.1: potassium carbonate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos / tert-butyl alcohol / 100 °C / Inert atmosphere

With sodium hydride; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tert-butyl XPhos; In N,N-dimethyl-formamide; mineral oil; tert-butyl alcohol;