3-(4-chlorobenzyl)-2-(3-chloro-4-isopropoxyphenylamino)-6-trifluoromethylquinazoline-4(3H)-one

Base Information

Chemical Name:3-(4-chlorobenzyl)-2-(3-chloro-4-isopropoxyphenylamino)-6-trifluoromethylquinazoline-4(3H)-one
CAS No.:1359816-48-0
Molecular Formula:C₂₅H₂₀Cl₂F₃N₃O₂
Molecular Weight:522.354
Hs Code.:

Synonyms:3-(4-chlorobenzyl)-2-(3-chloro-4-isopropoxyphenylamino)-6-trifluoromethylquinazoline-4(3H)-one

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Chemical Property of 3-(4-chlorobenzyl)-2-(3-chloro-4-isopropoxyphenylamino)-6-trifluoromethylquinazoline-4(3H)-one

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Technology Process of 3-(4-chlorobenzyl)-2-(3-chloro-4-isopropoxyphenylamino)-6-trifluoromethylquinazoline-4(3H)-one

There total 5 articles about 3-(4-chlorobenzyl)-2-(3-chloro-4-isopropoxyphenylamino)-6-trifluoromethylquinazoline-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1359818-10-2
3-(4-chlorobenzyl)-2-ethylthio-6-trifluoromethylquinazoline-4(3H)-one

: 5211-04-1
3-Chloro-4-isopropoxy-phenylamine

: 1359816-48-0
3-(4-chlorobenzyl)-2-(3-chloro-4-isopropoxyphenylamino)-6-trifluoromethylquinazoline-4(3H)-one

Guidance literature:: With acetic acid; In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 1h; Microwave irradiation;

Reference yield:

: 207981-46-2
2-fluoro-5-(trifluoromethyl)benzoyl chloride

: 1359816-48-0
3-(4-chlorobenzyl)-2-(3-chloro-4-isopropoxyphenylamino)-6-trifluoromethylquinazoline-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / dichloromethane / 1 h / 20 °C / Cooling with ice

2: 1-methyl-pyrrolidin-2-one / 0.5 h / 170 °C / Microwave irradiation

3: potassium carbonate / acetonitrile / 1 h / Reflux

4: acetic acid / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C / Microwave irradiation

With potassium carbonate; acetic acid; triethylamine; In 1-methyl-pyrrolidin-2-one; dichloromethane; acetonitrile;

Reference yield:

: N-(2-fluoro-5-trifluoromethylbenzoyl)-S-ethylthiourea

: 1359816-48-0
3-(4-chlorobenzyl)-2-(3-chloro-4-isopropoxyphenylamino)-6-trifluoromethylquinazoline-4(3H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1-methyl-pyrrolidin-2-one / 0.5 h / 170 °C / Microwave irradiation

2: potassium carbonate / acetonitrile / 1 h / Reflux

3: acetic acid / 1-methyl-pyrrolidin-2-one / 1 h / 150 °C / Microwave irradiation

With potassium carbonate; acetic acid; In 1-methyl-pyrrolidin-2-one; acetonitrile;