5211-04-1

Basic information

• Product Name: (3-chloro-4-isopropoxyphenyl)amine(SALTDATA: 0.85HCl)
• Synonyms: (3-chloro-4-isopropoxyphenyl)amine(SALTDATA: 0.85HCl);BenzenaMine, 3-chloro-4-(1-Methylethoxy)-
• CAS NO: 5211-04-1
• Molecular Formula: C₉H₁₂ClNO
• Molecular Weight: 185.65068
• Mol File: 5211-04-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (3-chloro-4-isopropoxyphenyl)amine(SALTDATA: 0.85HCl)(CAS DataBase Reference)
• NIST Chemistry Reference: (3-chloro-4-isopropoxyphenyl)amine(SALTDATA: 0.85HCl)(5211-04-1)
• EPA Substance Registry System: (3-chloro-4-isopropoxyphenyl)amine(SALTDATA: 0.85HCl)(5211-04-1)

Safety Data

• Hazardous Substances Data: 5211-04-1(Hazardous Substances Data)

Usage

Uses

3-Chloro-4-isopropoxy-phenylamine can be used to treat and prevent inflammatory, proliferative, and other kinase-mediated diseases. It can also be used as IgE and/or IgG receptor modulators to treat autoimmune diseases.

Upstream product

• 3964-52-1 2-chloro 4-aminophenol 
• 75-26-3 isopropyl bromide 
• 5210-99-1 2-Chloro-1-isopropoxy-4-nitro-benzene 

Downstream Products

• 1105633-90-6 C₁₉H₁₇ClN₂O₃ 
• 1105627-56-2 5-(4-(1,3-dioxolan-2-yl)phenyl)-N-(3-chloro-4-isopropoxyphenyl)isoxazole-3-carboxamide 
• 1105635-44-6 (S)-N-(3-chloro-4-isopropoxyphenyl)-5-(4-((2,2-dimethyl-1,3-dioxolan-4-yl)methoxy)phenyl)isoxazole-3-carboxamide 
• 1360118-40-6 6-(3-chloro-4-isopropoxyphenylimino)-3-(2-hydroxycarbonylethyl)-1-(4-methylbenzyl)-1,3,5-triazinane-2,4-dion 
• 70339-30-9 4'-(Isopropoxy)-3'-chloro-1-methoxycyclopropanecarboxanilide 

Relevant articles and documents

Discovery of Novel Sphingosine-1-Phosphate-1 Receptor Agonists for the Treatment of Multiple Sclerosis

The sphingosine-1-phosphate-1 (S1P1) receptor agonists have great potential for the treatment of multiple sclerosis (MS) because they can inhibit lymphocyte egress through receptor internalization. We designed and synthesized triazole and isoxazoline derivatives to discover a novel S1P1agonist for MS treatment. Of the two scaffolds, the isoxazoline derivative was determined to have excellent in vitro efficacy and drug-like properties. Among them, compound 21l was found to have superior drug-like properties as well as excellent in vitro efficacies (EC50= 7.03 nM in β-arrestin recruitment and EC50= 11.8 nM in internalization). We also confirmed that 21l effectively inhibited lymphocyte egress in the peripheral lymphocyte count test and significantly improved the clinical score in the experimental autoimmune encephalitis MS mouse model.