2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

Base Information

Chemical Name:2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide
CAS No.:1350473-14-1
Molecular Formula:C₁₇H₁₃N₅O
Molecular Weight:303.323
Hs Code.:

Synonyms:2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

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Chemical Property of 2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

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Technology Process of 2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

There total 8 articles about 2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1350473-45-8
2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

: 1350473-14-1
2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

Guidance literature:: 2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane;

With sodium acetate; In ethanol; at 60 ℃;

Reference yield:

: 875781-43-4
2-bromo-5H-pyrrolo[2,3-b]pyrazine

: 1350473-14-1
2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

2.2: pH 4

3.1: Jones reagent / water; acetone

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

4.2: 1 h / 0 - 20 °C

5.1: tricyclohexylphosphine; potassium phosphate / palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

6.1: water; aminosulfonic acid; potassium dihydrogenphosphate; sodium chloride / 1,4-dioxane / 2 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile

8.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

8.3: 60 °C

With potassium phosphate; potassium dihydrogenphosphate; Jones reagent; aminosulfonic acid; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium chloride; sodium hydroxide; tricyclohexylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; mineral oil;

Reference yield:

: 1185428-32-3
2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde

: 1350473-14-1
2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

1.2: 1 h / 0 - 20 °C

2.1: tricyclohexylphosphine; potassium phosphate / palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

3.1: water; aminosulfonic acid; potassium dihydrogenphosphate; sodium chloride / 1,4-dioxane / 2 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5.3: 60 °C

With potassium phosphate; potassium dihydrogenphosphate; aminosulfonic acid; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium chloride; tricyclohexylphosphine; palladium diacetate; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; mineral oil;