2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

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Chemical Name:2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide
CAS No.:1350473-45-8
Molecular Formula:C₂₃H₂₇N₅O₂Si
Molecular Weight:433.585
Hs Code.:

Synonyms:2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

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Chemical Property of 2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

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Technology Process of 2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

There total 7 articles about 2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1185428-39-0
2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid

: 2237-30-1
m-cyanoaniline

: 1350473-45-8
2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In acetonitrile;

Reference yield:

: 1334674-88-2
(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1350473-45-8
2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: Jones reagent / water; acetone

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

2.2: 1 h / 0 - 20 °C

3.1: tricyclohexylphosphine; potassium phosphate / palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

4.1: water; aminosulfonic acid; potassium dihydrogenphosphate; sodium chloride / 1,4-dioxane / 2 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile

With potassium phosphate; potassium dihydrogenphosphate; Jones reagent; aminosulfonic acid; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium chloride; tricyclohexylphosphine; palladium diacetate; In 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; mineral oil;

Reference yield:

: 1334674-87-1
(2-bromo-5-hydroxymethyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol

: 1350473-45-8
2-cyclopropyl-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (3-cyanophenyl)amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; water / tetrahydrofuran / 20 °C

1.2: pH 4

2.1: Jones reagent / water; acetone

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 20 °C

3.2: 1 h / 0 - 20 °C

4.1: tricyclohexylphosphine; potassium phosphate / palladium diacetate / toluene; water / 18 h / 100 °C / Inert atmosphere

5.1: water; aminosulfonic acid; potassium dihydrogenphosphate; sodium chloride / 1,4-dioxane / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / acetonitrile

With potassium phosphate; potassium dihydrogenphosphate; Jones reagent; aminosulfonic acid; water; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium chloride; sodium hydroxide; tricyclohexylphosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; water; N,N-dimethyl-formamide; acetone; toluene; acetonitrile; mineral oil;