benzyl 3α-{3-[2-(2-decanoyloxyethoxy)ethoxycarbonyl]propanoyloxy}-7α,12α-dihydroxy-5β-cholan-24-oate

Base Information

Chemical Name:benzyl 3α-{3-[2-(2-decanoyloxyethoxy)ethoxycarbonyl]propanoyloxy}-7α,12α-dihydroxy-5β-cholan-24-oate
CAS No.:1430196-58-9
Molecular Formula:C₄₉H₇₆O₁₁
Molecular Weight:841.136
Hs Code.:

Synonyms:benzyl 3α-{3-[2-(2-decanoyloxyethoxy)ethoxycarbonyl]propanoyloxy}-7α,12α-dihydroxy-5β-cholan-24-oate

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Chemical Property of benzyl 3α-{3-[2-(2-decanoyloxyethoxy)ethoxycarbonyl]propanoyloxy}-7α,12α-dihydroxy-5β-cholan-24-oate

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Technology Process of benzyl 3α-{3-[2-(2-decanoyloxyethoxy)ethoxycarbonyl]propanoyloxy}-7α,12α-dihydroxy-5β-cholan-24-oate

There total 5 articles about benzyl 3α-{3-[2-(2-decanoyloxyethoxy)ethoxycarbonyl]propanoyloxy}-7α,12α-dihydroxy-5β-cholan-24-oate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430196-49-8
3-[2-(2-decanoyloxyethoxy)ethoxycarbonyl]propanoyl chloride

: 105730-97-0
benzyl 3α,7α,12α-trihydroxyl-5β-cholestane-24-carboxylic ester

: 1430196-58-9
benzyl 3α-{3-[2-(2-decanoyloxyethoxy)ethoxycarbonyl]propanoyloxy}-7α,12α-dihydroxy-5β-cholan-24-oate

Guidance literature:: With dmap; In dichloromethane; at 0 - 22 ℃; for 0.75h;
DOI:10.1016/j.steroids.2013.02.001

Reference yield:

: 7735-31-1,61596-57-4
2-(2-benzyloxyethoxy)ethyl decanoate

: 1430196-58-9
benzyl 3α-{3-[2-(2-decanoyloxyethoxy)ethoxycarbonyl]propanoyloxy}-7α,12α-dihydroxy-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / dichloromethane / 2 h / 22 °C

2.1: oxalyl dichloride / toluene / 0.25 h / 22 °C

2.2: 0.33 h

3.1: dmap / dichloromethane / 0.75 h / 0 - 22 °C

With dmap; oxalyl dichloride; In dichloromethane; toluene;
DOI:10.1016/j.steroids.2013.02.001

Reference yield:

: 112-13-0
n-decanoyl chloride

: 1430196-58-9
benzyl 3α-{3-[2-(2-decanoyloxyethoxy)ethoxycarbonyl]propanoyloxy}-7α,12α-dihydroxy-5β-cholan-24-oate

Guidance literature:: Multi-step reaction with 5 steps

1.1: dmap; pyridine / dichloromethane / 2 h / 0 - 22 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 24 h / 40 °C

3.1: dmap / dichloromethane / 2 h / 22 °C

4.1: oxalyl dichloride / toluene / 0.25 h / 22 °C

4.2: 0.33 h

5.1: dmap / dichloromethane / 0.75 h / 0 - 22 °C

With pyridine; dmap; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; In dichloromethane; ethyl acetate; toluene;
DOI:10.1016/j.steroids.2013.02.001