Pyroglutamylglutamine

Base Information

Chemical Name:Pyroglutamylglutamine
CAS No.:109481-23-4
Molecular Formula:C₁₀H₁₅N₃O₅
Molecular Weight:257.246
Hs Code.:2933790090
DSSTox Substance ID:DTXSID201310949
Nikkaji Number:J1.854.617E
Wikidata:Q27161045
Mol file:109481-23-4.mol

Synonyms:Pyroglutamylglutamine;109481-23-4;PYR-GLN-OH;((S)-5-oxopyrrolidine-2-carbonyl)-L-glutamine;L-pyroglutamyl-L-glutamine;5-oxo-L-prolyl-L-glutamine;(2S)-5-amino-5-oxo-2-[[(2S)-5-oxopyrrolidine-2-carbonyl]amino]pentanoic acid;Pyro-L-glutaminyl-L-glutamine;p-Glu-Gln;5-oxoprolylglutamine;L-p-Glu-L-Gln;5-Oxo-Pro-Gln-OH;SCHEMBL159687;CHEBI:88956;ILAITOFTZJRIFJ-WDSKDSINSA-N;DTXSID201310949;MFCD00238328;CS-W023157;D77942;(2S)-4-CARBAMOYL-2-{[(2S)-5-OXOPYRROLIDIN-2-YL]FORMAMIDO}BUTANOIC ACID

Suppliers and Price of Pyroglutamylglutamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Pyr-Gln-OH
100mg
$ 960.00

TRC
Pyr-Gln-OH
10mg
$ 120.00

Total 10 raw suppliers

Chemical Property of Pyroglutamylglutamine

Chemical Property:

PSA：138.59000
LogP:-0.48010
Storage Temp.:-15°C
XLogP3:-2.2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:257.10117059
Heavy Atom Count:18
Complexity:382

Purity/Quality:

99% ^*data from raw suppliers

Pyr-Gln-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(=O)NC1C(=O)NC(CCC(=O)N)C(=O)O
Isomeric SMILES:C1CC(=O)N[C@@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Uses Pyr-Gln-OHis a dipeptide that is found in fruits, has a role as a human metabolite.

Technology Process of Pyroglutamylglutamine

There total 9 articles about Pyroglutamylglutamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13726-85-7
Boc-Gln-OH

: 109481-23-4
pyroGlu-Gln

Guidance literature:: Multi-step reaction with 4 steps

1: CH₃ONa / dimethylformamide

2: 4 N HCl / dioxane

3: i-PrNEt / dimethylformamide

4: aq. Na₂CO₃

With hydrogenchloride; i-PrNEt; sodium methylate; sodium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00141-7

Reference yield:

: 119706-08-0
BOC-Gln-OBg

: 109481-23-4
pyroGlu-Gln

Guidance literature:: Multi-step reaction with 3 steps

1: 4 N HCl / dioxane

2: i-PrNEt / dimethylformamide

3: aq. Na₂CO₃

With hydrogenchloride; i-PrNEt; sodium carbonate; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00141-7

Reference yield:

: (S)-2-Amino-4-carbamoyl-butyric acid (benzhydryl-carbamoyl)-methyl ester

: 109481-23-4
pyroGlu-Gln

Guidance literature:: Multi-step reaction with 2 steps

1: i-PrNEt / dimethylformamide

2: aq. Na₂CO₃

With i-PrNEt; sodium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(97)00141-7