119706-08-0Relevant academic research and scientific papers
TRH mimetics: Differentiation of antiamnesic potency from antidepressant effect
Mazurov, Anatoly A.,Andronati, Sergei A.,Korotenko, Tamara I.,Sokolenko, Nikolai I.,Dyadenko, Alexei I.,Shapiro, Yury E.,Gorbatyuk, Vitalii Ya.,Voronina, Tatyana A.
, p. 2029 - 2040 (2007/10/03)
For the purpose of rational modification of the TRH molecule, we were pursuing an approach that consists of two steps: (1) 'obligatory' replacement of histidine with glutamine in TRH and (2) the application of conformational constraints for putative bioac
N-BENZHYDRYL-GLYCOLAMIDE ESTERS (OBg ESTERS) AS CARBOXYL PROTECTING GROUPS IN PEPTIDE SYNTHESIS
Amblard, Muriel,Rodriguez, Marc,Martinez, Jean
, p. 5101 - 5108 (2007/10/02)
N-benzhydryl-glycolamide esters (OBg esters) of various N-protected amino acids have been synthesized.In order to demonstrate their usefulness in peptide chemistry, the syntheses of For-Met-Leu-Phe-OH (chemiotactic peptide) and Pro-Leu-Gly-NH2 (MIF) have been carried out.OBg esters are compatible with commonly used protecting groups and are cleanly and selectively removed in mild alkaline conditions without any side reaction, except for β-benzyl aspartyl containing sequences.
