(r)-6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-phenylethyl)amide

Base Information

Chemical Name:(r)-6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-phenylethyl)amide
CAS No.:840491-14-7
Molecular Formula:C₂₅H₂₄F₃N₅O₃
Molecular Weight:499.492
Hs Code.:

Synonyms:(r)-6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-phenylethyl)amide

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Chemical Property of (r)-6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-phenylethyl)amide

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Technology Process of (r)-6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-phenylethyl)amide

There total 6 articles about (r)-6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-phenylethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 840491-78-3
6-[4-(2-trifluoromethylbenzoyl)-piperazin-1-yl]pyridazine-3-carbonyl chloride

: 2549-14-6,1936-63-6
(R)-2-Amino-1-phenylethanol

: 840491-14-7
(r)-6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-phenylethyl)amide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1021/jm301661h

Reference yield:

: 312-94-7
2-trifluoromethylbenzoyl chloride

: 840491-14-7
(r)-6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-phenylethyl)amide

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 0 - 20 °C

2: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

3: tetra-(n-butyl)ammonium iodide; potassium carbonate / 1,4-dioxane / 24 h / Reflux

4: lithium hydroxide monohydrate / tetrahydrofuran; water / 6 h / 20 °C

5: thionyl chloride; N,N-dimethyl-formamide / chloroform / 18 h / Reflux

6: triethylamine / dichloromethane / 4 h / 20 °C

With thionyl chloride; lithium hydroxide monohydrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water;
DOI:10.1021/jm301661h

Reference yield:

: 840491-84-1
4-(2-trifluoromethylbenzoyl)piperazine-1-carboxylic acid t-butyl ester

: 840491-14-7
(r)-6-[4-(2-trifluoromethylbenzoyl)piperazin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-phenylethyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2: tetra-(n-butyl)ammonium iodide; potassium carbonate / 1,4-dioxane / 24 h / Reflux

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 6 h / 20 °C

4: thionyl chloride; N,N-dimethyl-formamide / chloroform / 18 h / Reflux

5: triethylamine / dichloromethane / 4 h / 20 °C

With thionyl chloride; lithium hydroxide monohydrate; tetra-(n-butyl)ammonium iodide; potassium carbonate; triethylamine; N,N-dimethyl-formamide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; chloroform; water;
DOI:10.1021/jm301661h