N-[4-(2-amino-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)phenyl]acetamide

Base Information

• Chemical Name: N-[4-(2-amino-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)phenyl]acetamide
• CAS No.: 331977-64-1
• Molecular Formula: C₂₀H₂₁N₃O₃
• Molecular Weight: 351.405
• Mol file: 331977-64-1.mol

Synonyms:N-(4-(2-amino-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)phenyl)acetamide

Chemical Property of N-[4-(2-amino-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)phenyl]acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(2-amino-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)phenyl]acetamide

There total 2 articles about N-[4-(2-amino-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

para-acetamidobenzaldehyde (122-85-0) + dimedone (126-81-8) + malononitrile (109-77-3) → N-(4-(2-amino-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)phenyl)acetamide (331977-64-1)

Guidance literature:

With L-proline; at 20 ℃; for 0.5h;

DOI:10.1055/s-2006-926227

Reference yield: 86.0%

N‐(4‐(2,2‐dicyanovinyl)phenyl)acetamide (26088-79-9) + dimedone (126-81-8) → N-(4-(2-amino-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)phenyl)acetamide (331977-64-1)

Guidance literature:

With piperidine; In ethanol; at 20 ℃; for 1h;

DOI:10.1002/jhet.5570410406

Reference yield: 74.0%

benzamidine monohydrochloride (1670-14-0) + N-(4-(2-amino-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)phenyl)acetamide (331977-64-1) → 4-amino-6-(4'-acetamidophenyl)-2-phenylpyrimidine-5-carbonitrile

Guidance literature:

benzamidine monohydrochloride; With sodium; In ethanol; for 0.25h; cooling;

N-(4-(2-amino-3-cyano-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromen-4-yl)phenyl)acetamide; In ethanol; for 72h; Heating;

DOI:10.1002/jhet.5570410406

upstream raw materials:

N‐(4‐(2,2‐dicyanovinyl)phenyl)acetamide

dimedone

para-acetamidobenzaldehyde

malononitrile