(1R)-1-{(S)-1-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}pentylamine

Base Information

• Chemical Name: (1R)-1-{(S)-1-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}pentylamine
• CAS No.: 503819-60-1
• Molecular Formula: C₂₀H₂₇NOS
• Molecular Weight: 329.506
• Mol file: 503819-60-1.mol

Synonyms:(1R)-1-{(S)-1-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}pentylamine

Chemical Property of (1R)-1-{(S)-1-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}pentylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-1-{(S)-1-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}pentylamine

There total 3 articles about (1R)-1-{(S)-1-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}pentylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

[1R,2S,(S)S]-N-{1-[(S)-(2-(p-toluenesulfinyl)phenyl)ethyl]pentyl}-p-toluenesulfinamide (503819-55-4) → (1R)-1-{(S)-1-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}pentylamine (503819-60-1)

Guidance literature:

With trifluoroacetic acid; In methanol; at 0 ℃; for 3h;

DOI:10.1021/ol027464h

Reference yield:

pentanal (110-62-3) → (1R)-1-{(S)-1-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}pentylamine (503819-60-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Ti(EtO)4

2.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 85 percent / tetrahydrofuran; hexane / -78 °C

3.1: 91 percent / TFA / methanol / 3 h / 0 °C

With titanium(IV) tetraethanolate; trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;

DOI:10.1021/ol027464h

Reference yield:

(S)-(+)-N-pentylidene-p-toluenesulfinamide (153277-55-5) → (1R)-1-{(S)-1-[(S)-2-(p-toluenesulfinyl)phenyl]ethyl}pentylamine (503819-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 85 percent / tetrahydrofuran; hexane / -78 °C

2.1: 91 percent / TFA / methanol / 3 h / 0 °C

With trifluoroacetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; hexane;

DOI:10.1021/ol027464h

upstream raw materials:

[1R,2S,(S)S]-N-{1-[(S)-(2-(p-toluenesulfinyl)phenyl)ethyl]pentyl}-p-toluenesulfinamide

pentanal

(S)-(+)-N-pentylidene-p-toluenesulfinamide

Downstream raw materials:

(1R)-1-[(S)-1-(phenyl)ethyl]pentylamine