(R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(triethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid

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Chemical Name:(R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(triethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid
CAS No.:1159611-58-1
Molecular Formula:C₆₄H₉₈O₁₆Si
Molecular Weight:1151.56
Hs Code.:

(R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(triethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid

Synonyms:(R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(triethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid

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Chemical Property of (R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(triethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid

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Technology Process of (R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(triethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid

There total 4 articles about (R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(triethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 994-30-9
triethylsilyl chloride

: 1159611-66-1
(R)-4-((2S,4S,6R)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-hydroxytetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid

: 1159611-58-1
(R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(triethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid

Guidance literature:: With dmap; In dichloromethane; at -15 - 20 ℃;
DOI:10.1021/ol900585t

Reference yield:

: 1159611-56-9
(R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(tert-butyldimethylsilyloxy)butyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(tert-butyldimethylsilyloxy) tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy) butanoic acid

: 1159611-58-1
(R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(triethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine hydrofluoride / tetrahydrofuran; pyridine / 48 h / 20 °C

2: dmap / dichloromethane / 1.5 h / -15 - 20 °C

With dmap; pyridine hydrofluoride; In tetrahydrofuran; pyridine; dichloromethane;

Reference yield:

: 1159611-65-0
(2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-(tert-butyldimethylsilyloxy)butyl)-2-((E)-4-((2R,6S)-6-(((2S,4S,6R)-4-(tert-butyldimethylsilyloxy)-6-((S)-4-hydroxy-2-(4-methoxybenzyloxy)butyl)tetrahydro-2H-pyran-2-yl)methyl)-4-methylenetetrahydro-2H-pyran-2-yl)-2-methylbut-3-en-2-yl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)tetrahydro-2H-pyran-3-yl octanoate

: 1159611-58-1
(R)-4-((2R,4S,6S)-6-(((2S,6R)-6-((E)-3-((2S,3S,6S,E)-6-((2R,3R)-3-(benzyloxymethoxy)-2-hydroxybutyl)-2-methoxy-4-(2-methoxy-2-oxoethylidene)-3-(octanoyloxy)tetrahydro-2H-pyran-2-yl)-3-methylbut-1-enyl)-4-methylenetetrahydro-2H-pyran-2-yl)methyl)-4-(triethylsilyloxy)tetrahydro-2H-pyran-2-yl)-3-(4-methoxybenzyloxy)butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.25 h / 0 °C

2: sodium chlorite; potassium dihydrogenphosphate / tert-butyl alcohol / 4 h / -10 - 20 °C

3: pyridine hydrofluoride / tetrahydrofuran; pyridine / 48 h / 20 °C

4: dmap / dichloromethane / 1.5 h / -15 - 20 °C

With dmap; sodium chlorite; potassium dihydrogenphosphate; pyridine hydrofluoride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine; dichloromethane; tert-butyl alcohol;