2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarboxamide

Base Information

Chemical Name:2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarboxamide
CAS No.:1185281-10-0
Molecular Formula:C₂₅H₂₃N₅O₃
Molecular Weight:441.489
Hs Code.:

Synonyms:2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarboxamide

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Chemical Property of 2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarboxamide

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Technology Process of 2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarboxamide

There total 16 articles about 2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185281-06-4
N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)-1H-imidazole-1-carboxamide

: 613-94-5
benzoic acid hydrazide

: 1185281-10-0
2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarboxamide

Guidance literature:: In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield:

: 409082-11-7
2-(2-methyl-5-nitrophenyl)acetonitrile

: 1185281-10-0
2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; potassium hydroxide / methanol / 14 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane / 14 h / Reflux

2.2: pH > 12

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

6.1: acetonitrile / 2 h / 20 °C

7.1: tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; water; hydrogen; potassium carbonate; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1185281-10-0
2-benzoyl-N-(3-(1,7-dimethyl-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-4-methylphenyl)hydrazinecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

3: acetonitrile / 2 h / 20 °C

4: tetrahydrofuran / 1 h / 20 °C

With potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene; acetonitrile;