α-(5-hydroxy-2-pentynyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Base Information

Chemical Name:α-(5-hydroxy-2-pentynyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile
CAS No.:234080-45-6
Molecular Formula:C₂₂H₂₃NO₃S
Molecular Weight:381.496
Hs Code.:

Synonyms:α-(5-hydroxy-2-pentynyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Suppliers and Price of α-(5-hydroxy-2-pentynyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of α-(5-hydroxy-2-pentynyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of α-(5-hydroxy-2-pentynyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

There total 6 articles about α-(5-hydroxy-2-pentynyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 234080-44-5
α-<5-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-pentynyl>-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

: 234080-45-6
α-(5-hydroxy-2-pentynyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1021/jm9804477

Reference yield:

: 28750-77-8
α-chloro-3,4-dimetoxybenzeneacetonitrile

: 234080-45-6
α-(5-hydroxy-2-pentynyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 65 percent / K₂CO₃ / acetonitrile / 12 h / 65 °C

2: 1.) NaH / 1.) THF, 1 h, 2.) THF, 1 h

3: 83 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / Ambient temperature

With tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm9804477

Reference yield:

: 90134-46-6
5-[(tert-butyldimethylsilyl)oxy]pent-2-yn-1-ol

: 234080-45-6
α-(5-hydroxy-2-pentynyl)-3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / N-bromosuccinimide, triphenylphosphine / CH₂Cl₂ / 1 h / -23 °C

2: 1.) NaH / 1.) THF, 1 h, 2.) THF, 1 h

3: 83 percent / tetrabutylammonium fluoride / tetrahydrofuran / 3 h / Ambient temperature

With N-Bromosuccinimide; tetrabutyl ammonium fluoride; sodium hydride; triphenylphosphine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm9804477