28750-77-8

Upstream product

• 7677-24-9 trimethylsilyl cyanide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 95392-01-1 2-(3,4-dimethoxyphenyl)-2-((trimethylsilyl)oxy)acetonitrile 
• 6309-18-8 2-(3,4-dimethoxyphenyl)-2-hydroxyacetonitrile 

Downstream Products

• 79714-35-5 5-(3,4-dimethoxyphenyl)thiazolidine-2,4-dione 
• 167159-69-5 α-(Cyclohexylthio)-3,4-dimethoxybenzeneacetonitrile 
• 113053-02-4 3,4-dimethoxy-α-<(4-methylphenyl)thio>benzeneacetonitrile 
• 123220-88-2 A-[(2-hydroxyethyl)-thio]-3,4-dimethoxy-benzeneacetonitrile 
• 167159-35-5 7-(2-Chloroethoxy)-α-(cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-2(1H)-isoquinolineheptanonitrile 
• 167158-97-6 7-(2-chloroethoxy)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinolineheptanenitrile 
• 167159-36-6 7-[5-(2-chloro-ethoxy)-6-methoxy-1,3-dihydro-isoindol-2-yl]-2-(3,4-dimethoxy-phenyl)-2-p-tolylsulfanyl-heptanenitrile 
• 167159-34-4 α-(Cyclohexylthio)-α-(3,4-dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-2(1H)-isoquinolineheptanenitrile 
• 167158-95-4 α-(3,4-Dimethoxyphenyl)-3,4-dihydro-7-hydroxy-6-methoxy-α-[(4-methylphenyl)thio]-2(1H)-isoquinoline-heptanenitrile 

Relevant academic research and scientific papers

A General Synthesis of 3,5-Dihalo-2H-1,4-oxazin-2-ones from Cyanohydrins

In a novel approach starting from O-trimethylsilyl protected or unprotected cyanohydrins and oxalyl chloride or bromide, a series of unknown 6-substituted 3,5-dihalo-2H-1,4-oxazin-2-ones were prepared.The method was shown to be efficient for various types of cyanohydrins; however cyclization was not obtained with cyanohydrins containing bulky substituents, electron-rich aryl or heteroaryl groups.A mechanism is proposed.