(6R,8S)-8-benzyl-6-(((tert-butyldiphenylsilyl)oxy)methyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

Base Information

Chemical Name:(6R,8S)-8-benzyl-6-(((tert-butyldiphenylsilyl)oxy)methyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine
CAS No.:1187063-32-6
Molecular Formula:C₃₄H₃₆N₄O₂Si
Molecular Weight:560.771
Hs Code.:

Synonyms:(6R,8S)-8-benzyl-6-(((tert-butyldiphenylsilyl)oxy)methyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (6R,8S)-8-benzyl-6-(((tert-butyldiphenylsilyl)oxy)methyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

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Technology Process of (6R,8S)-8-benzyl-6-(((tert-butyldiphenylsilyl)oxy)methyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

There total 3 articles about (6R,8S)-8-benzyl-6-(((tert-butyldiphenylsilyl)oxy)methyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: C₂₇H₃₀N₄O₂Si

: 100-39-0
benzyl bromide

: 1187063-32-6
(6R,8S)-8-benzyl-6-(((tert-butyldiphenylsilyl)oxy)methyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.orglett.9b01842

Reference yield: 87.0%

: 1187063-28-0
cis-6-(tert-butyl-diphenyl-silanyloxymethyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

: 100-39-0
benzyl bromide

: 1187063-32-6
(6R,8S)-8-benzyl-6-(((tert-butyldiphenylsilyl)oxy)methyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 4h; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tet.2009.06.033

Reference yield:

: 1187063-28-0
cis-6-(tert-butyl-diphenyl-silanyloxymethyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

: 100-39-0
benzyl bromide

: cis-8-benzyl-6-(tert-butyl-diphenyl-silanyloxymethyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

: 1187063-32-6
(6R,8S)-8-benzyl-6-(((tert-butyldiphenylsilyl)oxy)methyl)-8-phenyl-5,6-dihydro-8H-tetrazolo[5,1-c][1,4]oxazine

Guidance literature:: With sodium hydride; In tetrahydrofuran; at -5 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1016/j.tet.2009.06.033