(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(phenyl)methanone O-methyl oxime

Base Information

Chemical Name:(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(phenyl)methanone O-methyl oxime
CAS No.:1319194-36-9
Molecular Formula:C₂₈H₂₈N₄O₂
Molecular Weight:452.556
Hs Code.:

Synonyms:(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(phenyl)methanone O-methyl oxime

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Chemical Property of (2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(phenyl)methanone O-methyl oxime

Chemical Property:

Purity/Quality:

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Technology Process of (2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(phenyl)methanone O-methyl oxime

There total 6 articles about (2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(phenyl)methanone O-methyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1319194-23-4
(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(phenyl)methanone

: 593-56-6
N-methoxylamine hydrochloride

: 1319194-36-9
(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(phenyl)methanone O-methyl oxime

Guidance literature:: With pyridine; In methanol; for 41h; Reflux;

Reference yield:

: 29124-57-0
2-amino-5-bromobenzaldehyde

: 1319194-36-9
(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(phenyl)methanone O-methyl oxime

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; water / dimethyl sulfoxide / 4 h / 80 °C

1.2: 20 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / 85 °C / Inert atmosphere

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.17 h / 140 °C

4.1: tetrahydrofuran / 7 h / 60 °C

4.2: 20 °C

5.1: pyridine / methanol / 41 h / Reflux

With pyridine; potassium phosphate; water; potassium acetate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;

Reference yield:

: 5807-02-3
4-morpholinoacetonitrile

: 1319194-36-9
(2-(2-amino-3-morpholinoquinolin-6-yl)-3-methylphenyl)(phenyl)methanone O-methyl oxime

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide; water / dimethyl sulfoxide / 4 h / 80 °C

1.2: 20 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 18 h / 85 °C / Inert atmosphere

3.1: potassium phosphate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane; water / 0.17 h / 140 °C

4.1: tetrahydrofuran / 7 h / 60 °C

4.2: 20 °C

5.1: pyridine / methanol / 41 h / Reflux

With pyridine; potassium phosphate; water; potassium acetate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In tetrahydrofuran; 1,4-dioxane; methanol; water; dimethyl sulfoxide;