1-[2-(3-chloromethyl-2-methyl-phenylsulfanyl)-ethyl]-1H-[1,2,4]triazole

Base Information

Chemical Name:1-[2-(3-chloromethyl-2-methyl-phenylsulfanyl)-ethyl]-1H-[1,2,4]triazole
CAS No.:467252-71-7
Molecular Formula:C₁₂H₁₄ClN₃S
Molecular Weight:267.782
Hs Code.:

1-[2-(3-chloromethyl-2-methyl-phenylsulfanyl)-ethyl]-1<i>H</i>-[1,2,4]triazole

Synonyms:1-[2-(3-chloromethyl-2-methyl-phenylsulfanyl)-ethyl]-1H-[1,2,4]triazole

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Chemical Property of 1-[2-(3-chloromethyl-2-methyl-phenylsulfanyl)-ethyl]-1H-[1,2,4]triazole

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Technology Process of 1-[2-(3-chloromethyl-2-methyl-phenylsulfanyl)-ethyl]-1H-[1,2,4]triazole

There total 5 articles about 1-[2-(3-chloromethyl-2-methyl-phenylsulfanyl)-ethyl]-1H-[1,2,4]triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 467252-66-0
2-methyl-3-[2-(1H-1,2,4-triazol-1-yl)ethylsulfanyl]benzyl alcohol

: 467252-71-7
1-[2-(3-chloromethyl-2-methyl-phenylsulfanyl)-ethyl]-1H-[1,2,4]triazole

Guidance literature:: With thionyl chloride; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm0208673

Reference yield:

: 52130-17-3
3-amino-2-methylbenzoic acid

: 467252-71-7
1-[2-(3-chloromethyl-2-methyl-phenylsulfanyl)-ethyl]-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaNO₂; H⁺

1.2: potassium ethyl xanthogenate; aq. Na₂CO₃ / pH 8

1.3: 14.66 g / aq. NaOH / 20 h / Heating

2.1: 93 percent / H₂SO₄ / 48 h / Heating

3.1: 96 percent / LiAlH₄ / tetrahydrofuran / 2 h / Heating

4.1: 90 percent / K₂CO₃ / acetonitrile / 1 h / Heating

5.1: SOCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

With lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; hydrogen cation; potassium carbonate; sodium nitrite; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm0208673

Reference yield:

: 339354-89-1
2-methyl-3-sulfanylbenzyl alcohol

: 467252-71-7
1-[2-(3-chloromethyl-2-methyl-phenylsulfanyl)-ethyl]-1H-[1,2,4]triazole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / acetonitrile / 1 h / Heating

2: SOCl₂ / CH₂Cl₂ / 0.5 h / 20 °C

With thionyl chloride; potassium carbonate; In dichloromethane; acetonitrile;
DOI:10.1021/jm0208673