N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

Base Information

• Chemical Name: N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride
• CAS No.: 1322646-30-9
• Molecular Formula: C₂₆H₃₉N₃O₄S₂*ClH
• Molecular Weight: 558.206
• Mol file: 1322646-30-9.mol

Synonyms:N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

Chemical Property of N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride

There total 8 articles about N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine (1322645-18-0) → N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride (1322646-30-9)

Guidance literature:

With hydrogenchloride; In methanol; water; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/jm2002603

Reference yield:

C17H26N2O2S → N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride (1322646-30-9)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium tetrahydroborate / ethanol / 12 h / 20 °C / Inert atmosphere

2: sodium carbonate; sodium iodide / acetonitrile / 24 h / Inert atmosphere; Reflux

3: hydrogenchloride / methanol; water / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium tetrahydroborate; sodium carbonate; sodium iodide; In methanol; ethanol; water; acetonitrile;

DOI:10.1021/jm2002603

Reference yield:

N-(p-toluenesulfonamidopropyl)cyclohexylmethylamine (1322644-99-4) → N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine hydrochloride (1322646-30-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate; sodium iodide / acetonitrile / 24 h / Inert atmosphere; Reflux

2: hydrogenchloride / methanol; water / 4 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium carbonate; sodium iodide; In methanol; water; acetonitrile;

DOI:10.1021/jm2002603

upstream raw materials:

N-(p-toluenesulfonamidopropyl)cyclohexylmethylamine

N-(benzenesulfonyl)-N'-(p-toluenesulfonyl)bis(3-aminopropyl)cyclohexylmethylamine

N,N'-ditoluenesulfonyl-1,3-diaminopropane

N-(3-aminopropyl)-p-toluenesulfonamide