Furo[2,3-b]pyridine-2-carbonitrile (9CI)

Base Information

• Chemical Name: Furo[2,3-b]pyridine-2-carbonitrile (9CI)
• CAS No.: 109274-95-5
• Molecular Formula: C₈H₄N₂O
• Molecular Weight: 144.133
• Mol file: 109274-95-5.mol

Synonyms:Furo[2,3-b]pyridine-2-carbonitrile (9CI)

Chemical Property of Furo[2,3-b]pyridine-2-carbonitrile (9CI)

Chemical Property:

• PSA: 49.82000
• LogP: 1.69948

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Furo[2,3-b]pyridine-2-carbonitrile (9CI)

There total 2 articles about Furo[2,3-b]pyridine-2-carbonitrile (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

Furo[2,3-b]pyridine-2-carbaldehyde oxime (109274-93-3) → 2-cyanofuro<2,3-b>pyridine (109274-95-5)

Guidance literature:

With pyridine; 1,3,5-trichloro-2,4,6-triazine; In dichloromethane; for 1.5h; Heating;

Reference yield:

2-formylfuro<2,3-b>pyridine (109274-92-2) → 2-cyanofuro<2,3-b>pyridine (109274-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride, K₂CO₃ / aq. ethanol / 2 h / Ambient temperature

2: 75 percent / 2,4,6-trichloro-1,3,5-triazine, pyridine / CH₂Cl₂ / 1.5 h / Heating

With pyridine; 1,3,5-trichloro-2,4,6-triazine; hydroxylamine hydrochloride; potassium carbonate; In ethanol; dichloromethane;

Reference yield: 63.0%

2-cyanofuro<2,3-b>pyridine (109274-95-5) → furo<2,3-b>pyridine-2-carboxylic acid (34668-26-3)

Guidance literature:

With potassium hydroxide; In ethanol; for 2h; Heating;

upstream raw materials:

Furo[2,3-b]pyridine-2-carbaldehyde oxime

2-formylfuro<2,3-b>pyridine

Downstream raw materials:

furo<2,3-b>pyridine-2-carboxylic acid

Refernces