Furo[2,3-b]pyridine-2-carbaldehyde

Base Information

• Chemical Name: Furo[2,3-b]pyridine-2-carbaldehyde
• CAS No.: 109274-92-2
• Molecular Formula: C₈H₅NO₂
• Molecular Weight: 147.133
• European Community (EC) Number: 878-127-3
• DSSTox Substance ID: DTXSID201292044
• Nikkaji Number: J314.653G
• Mol file: 109274-92-2.mol

Synonyms:furo[2,3-b]pyridine-2-carbaldehyde;109274-92-2;furo[2,3-b]pyridine-2-carboxaldehyde;Furo[2,3-b]pyridine-2-carboxaldehyde (9CI);DTXSID201292044;furo[5,4-b]pyridine-2-carbaldehyde;AKOS015906640;AT21739;CS-0215135;EN300-226438;Z1255505540;20026-19-1

Chemical Property of Furo[2,3-b]pyridine-2-carbaldehyde

Chemical Property:

• PSA: 43.10000
• LogP: 1.64030
• Storage Temp.: 2-8°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 147.032028402
• Heavy Atom Count: 11
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

Furo[2,3-b]pyridine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(N=C1)OC(=C2)C=O

Technology Process of Furo[2,3-b]pyridine-2-carbaldehyde

There total 1 articles about Furo[2,3-b]pyridine-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

furo<2,3-b>pyridine (272-01-5) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2-formylfuro<2,3-b>pyridine (109274-92-2)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1) THF, hexane, -70 gradC, 15min 2)DMF, 4h, without cooling;

Reference yield: 88.0%

2-formylfuro<2,3-b>pyridine (109274-92-2) → 2-methylfuro<2,3-b>pyridine (75332-26-2)

Guidance literature:

With potassium hydroxide; hydrazine hydrate; In ethanol; for 1h; Heating;

Reference yield:

2-formylfuro<2,3-b>pyridine (109274-92-2) → 2-cyanofuro<2,3-b>pyridine (109274-95-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine hydrochloride, K₂CO₃ / aq. ethanol / 2 h / Ambient temperature

2: 75 percent / 2,4,6-trichloro-1,3,5-triazine, pyridine / CH₂Cl₂ / 1.5 h / Heating

With pyridine; 1,3,5-trichloro-2,4,6-triazine; hydroxylamine hydrochloride; potassium carbonate; In ethanol; dichloromethane;

upstream raw materials:

furo<2,3-b>pyridine

N,N-dimethyl-formamide

Downstream raw materials:

2-methylfuro<2,3-b>pyridine

furo<2,3-b>pyridine-2-carboxylic acid

2-cyanofuro<2,3-b>pyridine

Refernces