272-01-5Relevant articles and documents
Rhodium-Catalyzed Direct Arylation of Furopyridine: Synthesis and the Cardiac Effects of Dictamnine Derivatives
Du, Yufeng,Huang, Linyu,Wang, Neng,Li, Xiaohuan,Zhou, Xian-Li,Zhang, Lan,Huang, Shuai,Walsh, Patrick J.,Gao, Feng
, p. 1002 - 1008 (2022/02/07)
Herein is reported a Rh2(OAc)4/IMes ? HCl system that promotes the chemoselective installation of aryl groups at the 2-position of furo[2,3-b]pyridine (53–94% yields). The method is applicable to the direct modification of the natura
Synthesis of furo[2,3-b]pyridine
Chang, Meng-Yang,Tai, Hang-Yi
, p. 2373 - 2380 (2011/11/06)
Two synthetic routes toward furo[2,3-b]pyridine (1) starting with the known β,γ-unsaturated ester (3) are described.
Furopyridines. XII. Reaction of 3-Bromo, 2-Phenylthio and 2-Phenylthio-3-bromo Derivatives of Furo-, Furo-, Furo- and Furopyridine with Several Alkyllithiums
Shiotani, Shunsaku,Morita, Hiroyuki
, p. 413 - 422 (2007/10/02)
This paper describes reactions of 3-bromo- 1a-d, 2-phenylthio- 5a-d and 2-phenylthio-3-bromofuropyridines 6a-d with n-butyl-, t-butyl- and methyllithium and lithioacetonitrile.Lithiation of compounds 1a-d with n-butyl- or methyllithium gave the parent furopyridines 2a-d and o-ethynylpyridinols 3a-d.Reaction of compounds 5a-d with methyllithium afforded o-(phenylthioethynyl)pyridinols 7a-d, which were also yielded by reaction of compounds 6a-d with t-butyl- or methyllithium.The phenylthio group in compounds 7a-d were substituted with t-butyl group by the reaction with excess t-butyllithium.In contrast, 2-phenylthio group in compounds 5a-d and 6a-d was substituted with cyanomethyl group by reaction with lithioacetonitrile to give compounds 11a-d and 10b,c respectively.
