(R)-3-(5-methylpyridin-2-yl)-5-(methylsulfonyl)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)benzamide

Base Information

Chemical Name:(R)-3-(5-methylpyridin-2-yl)-5-(methylsulfonyl)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)benzamide
CAS No.:1186516-26-6
Molecular Formula:C₂₂H₂₀F₃N₃O₃S
Molecular Weight:463.48
Hs Code.:

Synonyms:(R)-3-(5-methylpyridin-2-yl)-5-(methylsulfonyl)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)benzamide

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Chemical Property of (R)-3-(5-methylpyridin-2-yl)-5-(methylsulfonyl)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)benzamide

Chemical Property:

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Technology Process of (R)-3-(5-methylpyridin-2-yl)-5-(methylsulfonyl)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)benzamide

There total 6 articles about (R)-3-(5-methylpyridin-2-yl)-5-(methylsulfonyl)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071435-61-4,886364-82-5
(1R)-1-[6-(trifluoromethyl)pyridin-3-yl]ethan-1-aminium chloride

: 3-(5-methylpyridin-3-yl)-5-(methylsulfonyl)benzoic acid hydrochloride

: 1186516-26-6
(R)-3-(5-methylpyridin-2-yl)-5-(methylsulfonyl)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 618-58-6
3,5-dibromobenzoic acid

: 1186516-26-6
(R)-3-(5-methylpyridin-2-yl)-5-(methylsulfonyl)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethyl sulfoxide / 4 h / 100 °C / Sealed tube

2.1: Chloro-oxo-acetic acid; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C

2.2: 3 h / 20 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 120 °C / Inert atmosphere; Microwave irradiation

5.1: barium dihydroxide / methanol / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With barium dihydroxide; Chloro-oxo-acetic acid; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; dimethyl sulfoxide; toluene;

Reference yield:

: 453566-01-3
methyl 3-bromo-5-(methylthio)benzoate

: 1186516-26-6
(R)-3-(5-methylpyridin-2-yl)-5-(methylsulfonyl)-N-(1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 120 °C / Inert atmosphere; Microwave irradiation

3: barium dihydroxide / methanol / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

With barium dihydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; toluene;