3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester

Base Information

Chemical Name:3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester
CAS No.:1161500-82-8
Molecular Formula:C₂₆H₂₅Cl₂FN₂O₄S
Molecular Weight:551.466
Hs Code.:

Synonyms:3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester

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Chemical Property of 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester

Chemical Property:

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Technology Process of 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester

There total 2 articles about 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 358971-49-0
1-[bis(4-chlorophenyl)methyl]azetidin-3-yl methanesulphonate

: 1161500-81-7
3-fluoro-5-methanesulphonylaminobenzoic acid ethyl ester

: 1161500-82-8
3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester

Guidance literature:: With potassium carbonate; In 4-methyl-2-pentanone; at 20 ℃; for 23h; Reflux;

Reference yield:

: 850807-08-8
5-amino-3-fluorobenzoic acid ethyl ester

: 1161500-82-8
3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / dichloromethane / 20 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / 4-methyl-2-pentanone / 23 h / 20 °C / Reflux

With pyridine; potassium carbonate; In dichloromethane; 4-methyl-2-pentanone;

Reference yield:

: 1161500-82-8
3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester

: 1161500-83-9
3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid

Guidance literature:: 3-({1-[bis(4-chlorophenyl)methyl]azetidin-3-yl}(methanesulphonyl)amino)-5-fluorobenzoic acid ethyl ester; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;

With disodium hydrogenphosphate; In tetrahydrofuran; water; pH=5;